Bamonte F, Albiero L, Ongini E
Acta Pharmacol Toxicol (Copenh). 1979 Aug;45(2):145-51. doi: 10.1111/j.1600-0773.1979.tb02374.x.
Reproductive and teratological studies were undertaken with netilmicin (Sch 20569), a new semisynthetic aminolgycoside antibiotic structurally related to sisomicin. The administration of 32 and 80 mg/kg/day, by the intramuscular route, in the rat prior to and during pregnancy and lactation did not affect the fertility of animals, the resorptions rate and the vitality of the litters until the second generation. Also in the rabbit, the dose of 32 mg/kg/day by intramuscular route during pregnancy did not cause any embryotoxic effect. No gross malformations were observed in both species. The minor skeletal malformation, described as "wavy ribs", was observed at a significant level only in the rat foetuses generated by dams treated with a dose as high as 80 mg/kg/day by the intramuscular route.
对新的半合成氨基糖苷类抗生素奈替米星（Sch 20569）进行了生殖和致畸学研究，其结构与西索米星相关。在大鼠怀孕前及怀孕和哺乳期，通过肌肉注射给予32和80毫克/千克/天的剂量，直到第二代，对动物的生育能力、吸收速率和幼崽活力均无影响。同样在兔子中，怀孕期通过肌肉注射给予32毫克/千克/天的剂量未引起任何胚胎毒性作用。在这两个物种中均未观察到明显的畸形。仅在通过肌肉注射给予高达80毫克/千克/天剂量的母鼠所产的大鼠胎儿中，观察到有少量骨骼畸形，表现为“波浪状肋骨”，且达到了显著水平。
