抗癌药1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀）在人和动物体内的生理分布。 - Suppr

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The physiological disposition of the carcinostatic 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in man and animals.

作者信息

DeVita V T, Denham C, Davidson J D, Oliverio V T

出版信息

Clin Pharmacol Ther. 1967 Jul-Aug;8(4):566-77. doi: 10.1002/cpt196784566.

DOI:10.1002/cpt196784566

PMID:4951973

Abstract

摘要

相似文献

The physiological disposition of the carcinostatic 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in man and animals.抗癌药1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀）在人和动物体内的生理分布。

Clin Pharmacol Ther. 1967 Jul-Aug;8(4):566-77. doi: 10.1002/cpt196784566.

Intrathecal chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea encapsulated into hybrid liposomes for meningeal gliomatosis: an experimental study.用包裹在杂化脂质体中的1,3-双(2-氯乙基)-1-亚硝基脲进行鞘内化疗治疗脑膜胶质瘤病：一项实验研究。

Cancer Res. 1996 Sep 1;56(17):3986-92.

Sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea of the EMT6 tumor in vivo as determined by both tumor volume response and in vitro plating assay.通过肿瘤体积反应和体外平板接种试验测定EMT6肿瘤在体内对1,3-双（2-氯乙基）-1-亚硝基脲和1-（2-氯乙基）-3-（4-甲基环己基）-1-亚硝基脲的敏感性。

Cancer Res. 1978 Aug;38(8):2395-400.

The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma pharmacokinetics and biotransformation of BCNU.苯巴比妥预处理对1,3-双(2-氯乙基)-1-亚硝基脲(BCNU)、1-(2-氯乙基)-3-环己基-1-亚硝基脲(CCNU)和1-(2-氯乙基)-3-(2,6-二氧代-3-哌啶基)-1-亚硝基脲(PCNU)抗肿瘤活性的影响，以及对BCNU血浆药代动力学和生物转化的影响。

J Pharmacol Exp Ther. 1979 Jan;208(1):1-6.

Microsomal metabolism of nitrosoureas.亚硝基脲的微粒体代谢

Cancer Res. 1975 Feb;35(2):296-301.

Analysis and distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in biological specimens.1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀）在生物样本中的分析与分布

Neurosurgery. 1983 Sep;13(3):230-3. doi: 10.1227/00006123-198309000-00002.

[Disruption of DNA synthesis and structure of mouse L1210 leukemia cells, sensitive and resistant to 1-methyl-1 nitrosourea and 1,3-bis(2-chloroethyl)-1-nitrosourea in vivo].[体内对1-甲基-1-亚硝基脲和1,3-双(2-氯乙基)-1-亚硝基脲敏感和耐药的小鼠L1210白血病细胞的DNA合成及结构破坏]

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Controlled delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea from ethylene-vinyl acetate copolymer.从乙烯-醋酸乙烯酯共聚物中控制释放1,3-双（2-氯乙基）-1-亚硝基脲

Cancer Res. 1989 Sep 15;49(18):5103-7.

Enhanced acute lung damage in mice following administration of 1,3-bis(2-chloroethyl)-1-nitrosourea.给予1,3-双(2-氯乙基)-1-亚硝基脲后小鼠急性肺损伤加重。

Cancer Res. 1985 Nov;45(11 Pt 2):5707-13.

Effect of thymidine on uptake, DNA alkylation, and DNA repair in L1210 cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea or 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine.

Cancer Res. 1988 Aug 1;48(15):4272-5.

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Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model.释放卡莫司汀的可吸收聚合物微芯片抑制大鼠9L侧腹模型中的肿瘤生长。

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Mass balance studies, with a focus on anticancer drugs.以抗癌药物为重点的质量平衡研究。

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Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.曲贝替定（Yondelis，原称ET-743），一项针对晚期癌症患者的质量平衡研究。

Invest New Drugs. 2005 Oct;23(5):429-36. doi: 10.1007/s10637-005-2902-4.

Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor--a pharmacokinetic study.在乙醇中进行卡莫司汀瘤内注射（DTI - 015）可增强对肿瘤的递送——一项药代动力学研究。

J Neurooncol. 2005 Jul;73(3):225-38. doi: 10.1007/s11060-004-5675-2.

Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia.谷胱甘肽、细胞增殖与1,3 - 双（2 - 氯乙基）- 1 - 亚硝基脲在K562白血病中的作用

J Clin Invest. 1993 Dec;92(6):2761-7. doi: 10.1172/JCI116894.

Cyclophosphamide, cisplatin, and carmustine: pharmacokinetics of carmustine following multiple alkylating-agent interactions.

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Distribution of Bratton-Marshall-positive material in mice following intravenous injections of nitrosoureas.静脉注射亚硝基脲后小鼠体内布拉顿 - 马歇尔阳性物质的分布情况。

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Vinylchloride: decomposition product of BCNU in vivo and in vitro.

Cancer Chemother Pharmacol. 1982 Dec;10(1):70-1. doi: 10.1007/BF00257243.

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