Iwarson S, Lundin P
Acta Med Scand. 1979;206(3):219-22. doi: 10.1111/j.0954-6820.1979.tb13498.x.
Four women who were treated with sulfonamides because of recurrent urinary tract infections experienced adverse liver reactions with jaundice during their third, fourth and fifth course of treatment, respectively. In spite of this, sulfonamide treatment was reinitiated some years later. Adverse liver reactions with jaundice recurred on all occasions. The clinical picture of the liver reactions was indistinguishable from that of viral hepatitis and a hepatitis-like reaction was also seen histologically. Signs of fibrosis appeared histologically after a third attack of jaundice associated with sulfonamides in one patient, but otherwise no persisting abnormalities were noted.
四名因复发性尿路感染接受磺胺类药物治疗的女性，分别在第三、第四和第五疗程中出现了伴有黄疸的不良肝脏反应。尽管如此，几年后仍再次开始使用磺胺类药物治疗。每次黄疸性不良肝脏反应均再次出现。肝脏反应的临床表现与病毒性肝炎无法区分，组织学检查也可见类似肝炎的反应。一名患者在第三次磺胺类药物相关黄疸发作后，组织学检查出现纤维化迹象，但除此之外未发现持续异常。
