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关于与人类心肌中的一种抗原发生交叉反应的β溶血性链球菌抗原的研究。

Studies on the antigen in beta-haemolytic streptococci that cross-reacts with an antigen in human myocardium.

作者信息

Nakhla L S, Glynn L E

出版信息

Immunology. 1967 Aug;13(2):209-18.

PMID:4952863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409314/
Abstract

A common antigen has been demonstrated in several serological types of Group A β-haemolytic streptococci. This antigen is cross-reactive with a cardiac and a voluntary muscle tissue antigen in man, the rabbit and the guinea-pig. The streptococcal antigen is present in smooth and matt variants of Group A streptococci, is absent from a type 24 Group A matt streptococcus, is present in Group G and absent from Groups C and D. It is distinguishable from the M type-specific antigen of Group A. The properties of the streptococcal and the cross-reacting tissue antigen have been studied. They are probably complex antigens of protein, polysaccharide and lipid. A similar antigen (or hapten), also cross-reacting with cardiac and voluntary muscle, has been found in human saliva. The salivary and the streptococcal antigens are probably related to the blood group substances. The salivary antigen (or hapten) could be successfully coated upon living streptococci but not upon a living .

摘要

在几种血清学类型的A组β溶血性链球菌中已证实存在一种共同抗原。这种抗原与人、兔和豚鼠的心脏及随意肌组织抗原有交叉反应。链球菌抗原存在于A组链球菌的光滑型和粗糙型变体中,24型A组粗糙型链球菌中不存在该抗原,G组中有该抗原,而C组和D组中没有。它可与A组的M型特异性抗原相区分。已对链球菌和交叉反应性组织抗原的特性进行了研究。它们可能是蛋白质、多糖和脂质的复合抗原。在人唾液中发现了一种类似的抗原(或半抗原),也与心脏和随意肌发生交叉反应。唾液抗原和链球菌抗原可能与血型物质有关。唾液抗原(或半抗原)可以成功地包被在活的链球菌上,但不能包被在活的……

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed6/1409314/db0f3f478ed7/immunology00403-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed6/1409314/db0f3f478ed7/immunology00403-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed6/1409314/db0f3f478ed7/immunology00403-0094-a.jpg

相似文献

1
Studies on the antigen in beta-haemolytic streptococci that cross-reacts with an antigen in human myocardium.关于与人类心肌中的一种抗原发生交叉反应的β溶血性链球菌抗原的研究。
Immunology. 1967 Aug;13(2):209-18.
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Myosin: a link between streptococci and heart.肌球蛋白:链球菌与心脏之间的联系。
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[Value of hemagglutination inhibition test in the detection of antibodies cross-reacting wit Streptococcus pyogenes and human heart antigens].[血凝抑制试验在检测与化脓性链球菌和人心脏抗原有交叉反应的抗体中的价值]
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引用本文的文献

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Streptococcal rheumatic carditis.链球菌性风湿性心脏病
Microbiol Rev. 1983 Mar;47(1):97-120. doi: 10.1128/mr.47.1.97-120.1983.
2
The thymus in rheumatic heart disease.风湿性心脏病中的胸腺。
Clin Exp Immunol. 1968 Jul;3(6):509-23.
3
M proteins of group A streptococci.A组链球菌的M蛋白

本文引用的文献

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Studies in experimental immunology of influenza. VII. An improved complement-fixation technique.流感实验免疫学研究。VII. 一种改进的补体结合技术。
Aust J Exp Biol Med Sci. 1951 Mar;29(2):137-46. doi: 10.1038/icb.1951.16.
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A specific soluble substance involved in nephrotoxic nephritis.一种参与肾毒性肾炎的特定可溶性物质。
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An immunological cross-reaction between group-A streptococcal cells and human heart tissue.A组链球菌细胞与人心脏组织之间的免疫交叉反应。
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The nature of experimental second-set kidney transplant rejection. 3. The role of complement.实验性二次肾移植排斥反应的本质。3. 补体的作用。
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Release of Fc-receptors after streptococcal lysis induced by a lytic enzyme from Streptomyces globisporus.由球形链霉菌的一种裂解酶诱导链球菌裂解后Fc受体的释放。
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Isolation and properties of a novel IgG-binding protein from streptococci of serological group U.从血清学U组链球菌中分离出一种新型IgG结合蛋白及其特性
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Common epitopes between mycobacterial and certain host tissue antigens.分枝杆菌与某些宿主组织抗原之间的共同表位。
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Characterization of a non-type-specific antigen(s) associated with group A streptococcal type 12 M protein.与A群链球菌12型M蛋白相关的一种非型特异性抗原的特性分析
Infect Immun. 1975 Jun;11(6):1300-6. doi: 10.1128/iai.11.6.1300-1305.1975.
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Group A streptococcal antigens cross-reactive with myocardium. Purification of heart-reactive antibody and isolation and characterization of the streptococcal antigen.与心肌发生交叉反应的A组链球菌抗原。心脏反应性抗体的纯化以及链球菌抗原的分离与特性鉴定。
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10
Streptococcal-induced cell-mediated-immune destruction of cardiac myofibers in vitro.体外链球菌诱导的心肌纤维细胞介导免疫破坏
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MILK INTOLERANCE IN GASTROINTESTINAL DISORDERS.胃肠道疾病中的牛奶不耐受
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Characterization of auto-antibodies produced in the rabbit by the injection of rat liver.通过注射大鼠肝脏在兔体内产生的自身抗体的特性分析。
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Secretion of blood-group substances in rheumatic fever. A genetic requirement for susceptibility?风湿热中血型物质的分泌。易感性的遗传因素?
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Immunologic studies of heart tissue. I. Production in rabbits of antibodies reactive with an autologous myocardial antigen following immunization with heterologous heart tissue.心脏组织的免疫学研究。I. 用异种心脏组织免疫后,兔体内产生与自体心肌抗原反应的抗体。
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