药物相互作用的临床效应。药物相互作用点的综述。
Clinical effects of interaction between drugs. Review of points at which drugs can interact.
作者信息
Macgregor A G
出版信息
Proc R Soc Med. 1965 Nov;58(11 Part 2):943-6. doi: 10.1177/003591576505811P201.
The prescribing of mixtures is unfortunately traditional and has a psychological appeal, which is being encouraged by many manufacturers. Doctors must have a sound working knowledge of the mode of action of modern drugs in order to use them effectively and safely, particularly when they are used together.In this context ;drug' means any biologically active substance. Interaction between drugs can be inapparent (if equal and opposite), antagonistic or synergistic. This includes summation and potentiation.INTERACTION BETWEEN DRUGS CAN ARISE IN A VARIETY OF WAYS: directly; in the intestine or other absorptive site; in transit; at the receptor or at another site in the same biological system; by accelerating or slowing drug metabolism; or by influencing excretion.Most of these mechanisms are considered in detail in this Symposium. With greater understanding of underlying mechanisms many of the untoward interactions now being increasingly reported might be foreseen and avoided.
不幸的是，开具复方制剂是一种传统做法，而且具有心理吸引力，许多制药厂商也在鼓励这种做法。医生必须对现代药物的作用方式有扎实的实用知识，以便有效且安全地使用它们，尤其是当多种药物联合使用时。在此背景下，“药物”指任何具有生物活性的物质。药物之间的相互作用可能不明显（如果作用相等且相反）、拮抗或协同。这包括相加和增强作用。药物之间的相互作用可通过多种方式产生：直接作用；在肠道或其他吸收部位；在转运过程中；在受体处或同一生物系统的其他部位；通过加速或减缓药物代谢；或通过影响排泄。本次研讨会将详细探讨其中的大多数机制。随着对潜在机制的深入了解，现在越来越多地报道的许多不良相互作用可能会被预见并避免。
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