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Evidence for function of a metal ion in the activity of dihydroorotase from Zymobacterium oroticum.

作者信息

Sander E G, Wright L D, McCormick D B

出版信息

J Biol Chem. 1965 Sep;240(9):3628-30.

PMID:4953711
Abstract
摘要

相似文献

1
Evidence for function of a metal ion in the activity of dihydroorotase from Zymobacterium oroticum.来自乳清酸发酵单胞菌的二氢乳清酸酶活性中金属离子功能的证据。
J Biol Chem. 1965 Sep;240(9):3628-30.
2
Enzyme elements involved in the interconversion of L-carbamylaspartate and L-dihydroorotate by dihydroorotase from Clostridium oroticum.来自乳清酸梭菌的二氢乳清酸酶催化L-氨甲酰天冬氨酸和L-二氢乳清酸相互转化过程中涉及的酶元件。
Arch Biochem Biophys. 1985 Dec;243(2):447-53. doi: 10.1016/0003-9861(85)90521-1.
3
Noncompetitive inhibition by substituted sulfonamides of dihydroorotase from Zymobacterium oroticum.来自乳清酸发酵单胞菌的二氢乳清酸酶被取代磺胺类药物的非竞争性抑制作用。
Life Sci. 1973 Dec 16;13(12):1747-52. doi: 10.1016/0024-3205(73)90121-5.
4
Purification of properties of dihydroorotase, a zinc-containing metalloenzyme in Clostridium oroticum.产氨短杆菌中含锌金属酶二氢乳清酸酶性质的纯化
J Bacteriol. 1976 Aug;127(2):863-73. doi: 10.1128/jb.127.2.863-873.1976.
5
Characterization of an orotic acid fermenting bacterium, zymobacterium oroticum, nov. gen., nov. spec.一种乳清酸发酵细菌——乳清酸发酵发酵单胞菌的鉴定，新属，新种
J Bacteriol. 1954 Oct;68(4):400-4. doi: 10.1128/jb.68.4.400-404.1954.
6
Dihydro-orotase from Clostridium oroticum. Purification and reversible removal of essential zinc.来自乳清酸梭菌的二氢乳清酸酶。纯化及必需锌的可逆去除
Biochem J. 1985 Aug 15;230(1):101-8. doi: 10.1042/bj2300101.
7
Purification and properties of dihydroorotase from Escherichia coli B.来自大肠杆菌B的二氢乳清酸酶的纯化及性质
Biochim Biophys Acta. 1971 Feb 10;227(2):442-52. doi: 10.1016/0005-2744(71)90075-1.
8
Evidence for a pH-dependent isomerization of Clostridium oroticum dihydroorotase.关于产氨棒杆菌二氢乳清酸酶pH依赖性异构化的证据。
Biochim Biophys Acta. 1985 Sep 20;831(1):159-60. doi: 10.1016/0167-4838(85)90164-5.
9
Flavin changes accompanying adaptation of Zymobacterium oroticum to orotate.伴随着乳清酸发酵单胞菌对乳清酸盐的适应过程中黄素的变化。
J Biol Chem. 1960 May;235:1533-5.
10
Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.二氢乳清酸酶的分子结构：通过使用双核金属中心进行催化的范例。
Biochemistry. 2001 Jun 19;40(24):6989-97. doi: 10.1021/bi010682i.

引用本文的文献

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Identification of Small Molecule Inhibitors against Dihydroorotase via HTS.通过高通量筛选鉴定二氢乳清酸酶的小分子抑制剂。
Int J Mol Sci. 2021 Sep 15;22(18):9984. doi: 10.3390/ijms22189984.
2
High-level expression, purification, and characterization of Staphylococcus aureus dihydroorotase (PyrC) as a cleavable His-SUMO fusion.金黄色葡萄球菌二氢乳清酸酶（PyrC）作为可裂解的His-SUMO融合蛋白的高效表达、纯化及特性分析
Protein Expr Purif. 2013 Mar;88(1):98-106. doi: 10.1016/j.pep.2012.11.018. Epub 2012 Dec 13.
3
Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form.
与抑制剂5-氟乳清酸复合的大肠杆菌二氢乳清酸酶T109S突变体的结构：催化活性由晶体形态反映。
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):154-61. doi: 10.1107/S1744309107004009. Epub 2007 Feb 13.
4
Purification and characterization of dihydroorotase from Pseudomonas putida.恶臭假单胞菌中二氢乳清酸酶的纯化与特性分析
Arch Microbiol. 1995 Nov;164(5):353-7. doi: 10.1007/BF02529982.
5
Pyrimidine metabolism in microorganisms.微生物中的嘧啶代谢
Bacteriol Rev. 1970 Sep;34(3):278-343. doi: 10.1128/br.34.3.278-343.1970.
6
Dihydro-orotase from Clostridium oroticum. Purification and reversible removal of essential zinc.来自乳清酸梭菌的二氢乳清酸酶。纯化及必需锌的可逆去除
Biochem J. 1985 Aug 15;230(1):101-8. doi: 10.1042/bj2300101.
7
Mammalian dihydroorotase: nucleotide sequence, peptide sequences, and evolution of the dihydroorotase domain of the multifunctional protein CAD.哺乳动物二氢乳清酸酶：多功能蛋白CAD中二氢乳清酸酶结构域的核苷酸序列、肽序列及进化
Proc Natl Acad Sci U S A. 1990 Jan;87(1):174-8. doi: 10.1073/pnas.87.1.174.
8
Degradation of purines and pyrimidines by microorganisms.微生物对嘌呤和嘧啶的降解
Bacteriol Rev. 1976 Jun;40(2):403-68. doi: 10.1128/br.40.2.403-468.1976.
9
Purification of properties of dihydroorotase, a zinc-containing metalloenzyme in Clostridium oroticum.产氨短杆菌中含锌金属酶二氢乳清酸酶性质的纯化
J Bacteriol. 1976 Aug;127(2):863-73. doi: 10.1128/jb.127.2.863-873.1976.