长期以低于高血压剂量静脉输注去甲肾上腺素对清醒犬射血分数的影响。（备注：这里的译文不太准确，原英文表述更侧重于说长期亚高血压剂量输注去甲肾上腺素使清醒犬射血分数增加，更准确译文：长期以低于高血压剂量静脉输注去甲肾上腺素可使清醒犬的射血分数增加。）严格按要求则是：在清醒犬中，长期以低于高血压剂量静脉输注去甲肾上腺素所产生的射血分数增加。

Increased ejection fraction produced by a long-term subhypertensive infusion of norepinephrine in the conscious dog.

作者信息

Laks M M, Garner D, Wong V

出版信息

Am Heart J. 1979 Dec;98(6):732-5. doi: 10.1016/0002-8703(79)90471-x.

Abstract

Five mongrel dogs with chronically implanted catheters in the left atrium, mid-thoracic aorta, and right atrium were continuously infused with subhypertensive doses of norepinephrine for 3 months. Left ventricular cineangiography, determinations of aortic pressure, and cardiac output were performed in the conscious dog. After 3 months of continuous norepinephrine infusion, stroke volume increased from 38 +/- 3.0 to 67 +/- 8.0 ml. (p less than .01), the left ventricular end-diastolic volume increased from 72 +/- 6.4 to 89 +/- 12.9 ml. (p less than .05), and the ejection fraction increased from 52 +/- 3.6 to 76 +/- 3.6% (p less than .005). We postulate that norepinephrine results in an increased myocardial function by producing physiological myocardial hypertrophy.

摘要

五只杂种狗的左心房、胸主动脉中部和右心房长期植入导管，连续3个月给予亚高血压剂量的去甲肾上腺素。在清醒的狗身上进行左心室电影血管造影、主动脉压力测定和心输出量测定。连续输注去甲肾上腺素3个月后，每搏量从38±3.0毫升增加到67±8.0毫升（p<0.01），左心室舒张末期容积从72±6.4毫升增加到89±12.9毫升（p<0.05），射血分数从52±3.6%增加到76±3.6%（p<0.005）。我们推测，去甲肾上腺素通过产生生理性心肌肥大导致心肌功能增强。