布氏锥虫可溶性抗原的变异
Variation of the soluble antigens of Trypanosoma brucei.
作者信息
Miller J K
出版信息
Immunology. 1965 Dec;9(6):521-8.
Abstract
Specific changes in the soluble antigens (exoantigen) of have been studied in relation to the process of antigenic variation. Such antigens, prepared from variant substrains of trypanosomes, were compared immunologically by agglutination, precipitin and mouse protection tests. Direct and absorption tests demonstrated that specific antibodies were produced to the exoantigen of each variant population and that the immunogenicity of the antigenic components decreases as infection proceeds.
摘要
已针对抗原变异过程研究了锥虫可溶性抗原（外抗原）的特定变化。从锥虫变异亚菌株制备的此类抗原，通过凝集、沉淀素和小鼠保护试验进行了免疫学比较。直接试验和吸收试验表明，针对每个变异群体的外抗原产生了特异性抗体，并且随着感染的进行，抗原成分的免疫原性降低。
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