Sadowski J, Kurkus J, Gellert R
Am J Physiol. 1979 Oct;237(4):F262-7. doi: 10.1152/ajprenal.1979.237.4.F262.
The function of the innervated and denervated kidney was examined in clearance studies with unilaterally renal-denervated conscious and anesthetized dogs before and after saline loading. Barbiturate anesthesia distinctly depressed hemodynamics and excretory function of both kidneys and increased the difference between the denervated and innervated organ. In conscious moderately hydrated dogs the denervated kidney excreted slightly more sodium and water, while after saline loading higher excretion was observed on the innervated side. The denervated-to-innervated kidney ratios for UNaV, UNaV/100 ml GFR, and urine flow fell significantly from mean control values of 1.27, 1.27, and 1.20, respectively, to 0.80, 0.87, and 0.77 after extracellular volume expansion. Similar alterations of the ratios were observed in anesthetized dogs, but higher excretion of the denervated kidney persisted after saline loading. It is concluded that the greater natriuretic response of the intact kidney to saline infusion was due to inhibition of sodium-retaining action of renal efferent nerve activity by acute extracellular volume expansion.
在对单侧肾去神经支配的清醒和麻醉犬进行的清除率研究中，在生理盐水负荷前后对去神经支配和未去神经支配的肾脏功能进行了检查。巴比妥类麻醉明显抑制了双侧肾脏的血流动力学和排泄功能，并增加了去神经支配和未去神经支配器官之间的差异。在清醒的适度水合犬中，去神经支配的肾脏排泄的钠和水略多，而在生理盐水负荷后，未去神经支配侧的排泄量更高。去神经支配肾脏与未去神经支配肾脏的尿钠排泄量（UNaV）、每100ml肾小球滤过率的尿钠排泄量（UNaV/100 ml GFR）和尿流率比值，在细胞外液量扩张后，分别从平均对照值1.27、1.27和1.20显著降至0.80、0.87和0.77。在麻醉犬中观察到了类似的比值变化，但在生理盐水负荷后，去神经支配肾脏的排泄量仍然较高。得出的结论是，完整肾脏对生理盐水输注的更大利钠反应是由于急性细胞外液量扩张抑制了肾传出神经活动的保钠作用。
