区域化疗作为手术辅助手段：一项实验研究。
Regional chemotherapy as an adjunct to surgery: an experimental study.
作者信息
Thurston O G, Couves C M
出版信息
Can Med Assoc J. 1966 Nov 26;95(22):1149-51.
Using the Walker 256 tumour in the hind limb of the rat as an experimental model, regional chemotherapy (isolation perfusion and intra-arterial infusion) was used as a pre-surgical adjunct in order to evaluate further the role of chemotherapy combined with surgery. There was an impressive and significant increase in the number of animals surviving free of tumour for 60 days when regional chemotherapy was carried out with triethylenethiophosphoramide (ThioTEPA). Intra-arterial infusion is a simpler procedure and affords the same improvement as does isolation perfusion.We must continue to assess critically the role of regional chemotherapy combined with surgery in human tumours.
以大鼠后肢的Walker 256肿瘤作为实验模型，采用区域化疗（隔离灌注和动脉内输注）作为术前辅助手段，以进一步评估化疗联合手术的作用。当用三乙烯硫代磷酰胺（噻替派）进行区域化疗时，存活60天无肿瘤的动物数量有了显著且令人印象深刻的增加。动脉内输注是一种更简单的方法，与隔离灌注具有相同的改善效果。我们必须继续严格评估区域化疗联合手术在人类肿瘤中的作用。
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