Ohtani M, Kikuchi H, Kitahata L M, Taub A, Toyooka H, Hanaoka K, Dohi S
Anesthesiology. 1979 Nov;51(5):414-7. doi: 10.1097/00000542-197911000-00009.
Anatomic, physiologic and behavioral evidence suggests that the neurons in the nucleus reticularis gigantocellularis of the medial medullary reticular formation may act as a relay station for the transmission of nociceptive information from the spinal cord to higher brain centers. The nucleus reticularis gigantocellularis may also be the site of action of analgesic agents, such as ketamine hydrochloride. Utilizing extracellular microelectrodes in 23 decerebrate cats, the authors measured the effect of ketamine on neurons in the nucleus reticularis gigantocellularis that were excited by electrical stimulation of peripheral nerves. The frequency of spontaneous single-unit firing activity in the nucleus reticularis gigantocellularis was suppressed by 31 +/- 11 (mean +/- 1 SE) and by 62 +/- 7 per cent with ketamine, 1.0 and 2.5 mg/kg, iv, respectively. The frequency of evoked single-unit activity was suppressed by 57 +/- 9 and 79 +/- 5 per cent with ketamine, 1.0 and 2.5 mg/kg, respectively. Ketamine produces significant depression of single-unit activity of the cells in the nucleus reticularis gigantocellularis, suggesting that this may be an important site of its analgesic action.
解剖学、生理学及行为学证据表明，延髓内侧网状结构的巨细胞网状核中的神经元可能作为痛觉信息从脊髓向高级脑中枢传递的中继站。巨细胞网状核也可能是诸如盐酸氯胺酮等镇痛药的作用部位。作者使用细胞外微电极对23只去大脑猫进行研究，测量了氯胺酮对因外周神经电刺激而兴奋的巨细胞网状核中神经元的影响。静脉注射1.0和2.5mg/kg氯胺酮时，巨细胞网状核中自发单单位放电活动的频率分别被抑制31±11（平均值±1标准误）和62±7%。静脉注射1.0和2.5mg/kg氯胺酮时，诱发单单位活动的频率分别被抑制57±9和79±5%。氯胺酮可显著抑制巨细胞网状核中细胞的单单位活动，提示这可能是其镇痛作用的一个重要部位。
