一种新型三氮烯咪唑的广谱抗菌活性
Broad-spectrum antimicrobial activity of a new triazenoimidazole.
作者信息
Pittillo R F, Hunt D E
出版信息
Appl Microbiol. 1967 May;15(3):531-2. doi: 10.1128/am.15.3.531-532.1967.
Abstract
Methyl-5(or 4)-(3,3-dimethyl-1-triazeno)-imidazole-4(or 5)-carboxylate was shown to have in vitro antimicrobial activity against gram-positive and gram-negative bacteria, yeasts, filamentous fungi, and algae. Preliminary studies with mice, experimentally infected with Staphylococcus aureus, have shown that this new antimicrobial agent has in vivo chemotherapeutic activity comparable to that observed with penicillin.
摘要
5（或4）-甲基-（3,3-二甲基-1-三氮烯）-咪唑-4（或5）-羧酸甲酯已被证明对革兰氏阳性菌和革兰氏阴性菌、酵母、丝状真菌及藻类具有体外抗菌活性。对实验感染金黄色葡萄球菌的小鼠进行的初步研究表明，这种新型抗菌剂的体内化疗活性与青霉素相当。
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Biochem Pharmacol. 1962 Jul;11:674-6. doi: 10.1016/0006-2952(62)90130-2.
2
Complete inhibition of mouse leukaemia L1210 by 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide (NSC-82196).5（或4）-[3,3-双（2-氯乙基）-1-三氮烯基]咪唑-4（或5）-甲酰胺（NSC-82196）对小鼠白血病L1210的完全抑制作用
Nature. 1966 Apr 9;210(5032):208-9. doi: 10.1038/210208a0.
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Antifungal action of 1,3-bis(2-chloroethyl)-1-nitrosourea.1,3-双(2-氯乙基)-1-亚硝基脲的抗真菌作用
Antimicrob Agents Chemother (Bethesda). 1965;5:710-6.
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A new antifungal and antibacterial agent, methyl 5(or 4)-(3,3-dimethyl-1-triazeno)imidazole-4(or 5)-carboxylate.一种新型抗真菌和抗菌剂，5（或4）-（3,3-二甲基-1-三氮烯基）咪唑-4（或5）-羧酸甲酯。
J Pharm Sci. 1967 Jan;56(1):147-8. doi: 10.1002/jps.2600560133.
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