Pitt B R, Radford E P, Gurtner G H, Traystman R J
Arch Environ Health. 1979 Sep-Oct;34(5):345-9.
Significant elevations of carboxyhemoglobin and blood cyanide have been found in fire victims. The nature of the interaction of acute exposures to these agents is unclear. This study was undertaken to describe the of cyanide and carbon monoxide--alone and in combination--on the circulation and metabolism of the brain in anesthetized dogs. Cerebral blood flow increased to 130 and 200% of control with elevations in carboxyhemoglobin to 30 and 51% or with elevations in blood cyanide to 1.0 and 1.5 microgram/ml, respectively. Cerebral oxygen consumption remained unchanged until the higher level of carbon monoxide or cyanide was reached. When carbon monoxide and cyanide were administered simultaneously, cerebral blood flow increased in an additive manner, but significant decreases in cerebral oxygen consumption occurred at the combination of the lower concentrations. These data suggest that carbon monoxide and cyanide are physiologically additive on producing changes in cerebral blood flow, but may act synergistically on cerebral metabolism.
火灾受害者的碳氧血红蛋白和血氰化物水平显著升高。急性接触这些物质之间相互作用的性质尚不清楚。本研究旨在描述氰化物和一氧化碳单独及联合作用于麻醉犬脑循环和代谢的情况。随着碳氧血红蛋白分别升高至30%和51%，或血氰化物分别升高至1.0微克/毫升和1.5微克/毫升，脑血流量增加至对照值的130%和200%。在达到较高水平的一氧化碳或氰化物之前，脑氧耗量保持不变。当同时给予一氧化碳和氰化物时，脑血流量以相加的方式增加，但在较低浓度组合时脑氧耗量显著降低。这些数据表明，一氧化碳和氰化物在引起脑血流量变化方面具有生理相加作用，但在脑代谢方面可能具有协同作用。
