对疟疾的免疫：对诺氏疟原虫抗原变异的抗体反应。
Immunity to malaria: the antibody response to antigenic variation by Plasmodium knowlesi.
作者信息
Brown I N, Brown K N, Hills L A
出版信息
Immunology. 1968 Jan;14(1):127-38.
Abstract
Monkey erythrocytes infected with schizonts of are agglutinated when mixed with serum taken from chronically infected monkeys (Eaton, 1938). This reaction has proved highly specific and capable of distinguishing antigenic variants of one strain. Chronic infections of in rhesus monkeys are maintained by a succession of antigenically distinct populations, each population stimulating a specific agglutinin response. Additional agglutinins which are not variant specific are found at low titre in sera taken after an infection has persisted for a month or more. The possible relevance of these observations to protective immunity is discussed.
摘要
感染疟原虫裂殖体的猴红细胞与慢性感染猴的血清混合时会发生凝集（伊顿，1938年）。这一反应已被证明具有高度特异性，能够区分同一菌株的抗原变体。恒河猴体内疟原虫的慢性感染是由一系列抗原性不同的群体维持的，每个群体都会刺激产生特定的凝集素反应。在感染持续一个月或更长时间后采集的血清中，发现了效价较低的非变体特异性额外凝集素。讨论了这些观察结果与保护性免疫的可能相关性。
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