Hicks G L, Zwart H H, DeWall R A
Arch Surg. 1979 Nov;114(11):1285-7. doi: 10.1001/archsurg.1979.01370350087009.
Controversy continues about the oxygenator preferable for cardiopulmonary bypass (CPB). This prospective study was undertaken in 52 patients undergoing coronary bypass surgery. Oxygenators were alternated each case between model Q-100, Bentley Laboratories Inc, Irvine, Calif, and Travenol Membrane Oxygenator (TMO), Travenol Laboratories Inc, Deerfield, Ill. The Q-100 group required higher CPB O2 flows, but PO2 levels during CPB were similar for both groups. Heparin sodium dosage and activated clotting, bleeding, prothrombin, and partial thromboplastin times were identical in both groups. Blood loss and platelet reduction after CPB were also similar. Postoperative complications in the Q-100 group included one myocardial infarction, and one neurological problem. The TMO group had no myocardial infarction and one neurological problem. The membrane oxygenator took nine minutes longer to set up and was $63 more expensive to purchase. Blood trauma during CPB was less with the membrane oxygenator (lower plasma hemoglobin level), but we conclude that both oxygenators performing adequately during clinical use in open heart surgery.
关于体外循环（CPB）中哪种氧合器更优仍存在争议。本前瞻性研究纳入了52例行冠状动脉搭桥手术的患者。在每例患者中，交替使用加利福尼亚州欧文市本特利实验室公司生产的Q - 100型氧合器和伊利诺伊州迪尔菲尔德市特拉文诺实验室公司生产的特拉文诺膜式氧合器（TMO）。Q - 100组需要更高的CPB氧流量，但两组在CPB期间的PO2水平相似。两组的肝素钠用量以及活化凝血时间、出血时间、凝血酶原时间和部分凝血活酶时间均相同。CPB后的失血量和血小板减少情况也相似。Q - 100组的术后并发症包括1例心肌梗死和1例神经问题。TMO组无心肌梗死，有1例神经问题。膜式氧合器的安装时间长9分钟，购买价格贵63美元。CPB期间膜式氧合器造成的血液损伤较小（血浆血红蛋白水平较低），但我们得出结论，在心脏直视手术的临床使用中，两种氧合器均表现良好。
