Schussler G C, Vance V K
J Clin Invest. 1968 Apr;47(4):720-8. doi: 10.1172/JCI105767.
The relationship between free thyroxine concentration and thyroxine turnover was studied during thyroid suppression with triiodothyronine. Although there was some increase in the proportion of serum thyroxine bound to thyroxine-binding globulin, the ratio of ultrafilterable to protein-bound hormone was not significantly affected. The fractional disappearance rate of thyroxine increased from an average control value of 11.47%/day to 14.72%/day. Because of contraction of the thyroxine distribution space the clearance of thyroxine was less markedly affected, increasing from 1.37 to 1.56 liters/day. Since the ratio of thyroxine turnover to free thyroxine concentration, i.e., the free thyroxine clearance, increased proportionately (4.79-5.55 liters x 10(3)/day) we conclude that triiodothyronine stimulates thyroxine clearance by a mechanism that is independent of effects on free thyroxine concentration.
在使用三碘甲状腺原氨酸进行甲状腺抑制期间，研究了游离甲状腺素浓度与甲状腺素周转率之间的关系。尽管与甲状腺素结合球蛋白结合的血清甲状腺素比例有所增加，但可超滤的激素与蛋白结合激素的比例并未受到显著影响。甲状腺素的分数消失率从平均对照值的11.47%/天增加到14.72%/天。由于甲状腺素分布空间的缩小，甲状腺素的清除率受影响较小，从1.37升/天增加到1.56升/天。由于甲状腺素周转率与游离甲状腺素浓度的比值，即游离甲状腺素清除率，成比例增加（4.79 - 5.55升×10³/天），我们得出结论，三碘甲状腺原氨酸通过一种独立于对游离甲状腺素浓度影响的机制刺激甲状腺素清除。
