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猴子的睡眠模式与大脑血清素浓度:对氯苯丙氨酸的影响。

Sleep patterns of the monkey and brain serotonin concentration: effect of p-chlorophenylalanine.

作者信息

Weitzman E D, Rapport M M, McGregor P, Jacoby J

出版信息

Science. 1968 Jun 21;160(3834):1361-3. doi: 10.1126/science.160.3834.1361.

DOI:10.1126/science.160.3834.1361
PMID:4967983
Abstract

The amount of time that monkeys (Macaca mulatta) slept was reduced after they were given p-chlorophenylalanine, a selective depletor of serotonin in animal tissues. The time spent in the rapid eye movement stage of sleep was unchanged, but the time in other sleep stages decreased. Seven regions of the brain had a 31 to 46 percent decrease in serotonin content; the concentration of cerebellar serotonin increased by 44 percent.

摘要

给恒河猴注射对氯苯丙氨酸(一种动物组织中血清素的选择性消耗剂)后,它们的睡眠时间减少。快速眼动睡眠阶段的时长没有变化,但其他睡眠阶段的时长减少。大脑的七个区域血清素含量下降了31%至46%;小脑血清素浓度增加了44%。

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