Lupulescu A, Potorac E, Pop A, Heitmanek C, Merculiev E, Chisiu N, Oprisan R, Neacsu C
Immunology. 1968 Apr;14(4):475-82.
Repeated inoculation of homologous parathyroid tissue in dogs induced isoimmune hypoparathyroidism, with all the characteristic biochemical and histopathological features and the presence of complement fixing antibodies in the serum. Disturbances of calcium and phosphorus metabolism were similar to, but less severe than, those observed in dogs with hypoparathyroidism induced by complete thyro-parathyroidectomy. Injection of rabbits with crude extracts of dog, rat, hog and human parathyroid or with bovine parathormone (PTH), each incorporated in Freund's adjuvant, resulted in the development of complement fixing and precipitating antibodies: these reacted with the corresponding tissue preparations, but did not show cross-reactivity. Antibodies were not detected in the serum of normal dogs or in control dogs inoculated with Freund's adjuvant alone. Study of the parathyroid glands by electron microscopy provided information on the mechanism of PTH secretion and synthesis in normal dogs and in those with hypoparathyroidism.
在犬类中反复接种同源甲状旁腺组织可诱发同种免疫性甲状旁腺功能减退症，伴有所有典型的生化和组织病理学特征，且血清中存在补体结合抗体。钙和磷代谢紊乱与完全甲状腺-甲状旁腺切除术后诱发甲状旁腺功能减退症的犬类相似，但程度较轻。给兔子注射狗、大鼠、猪和人甲状旁腺的粗提物或牛甲状旁腺激素（PTH），每种都加入弗氏佐剂，可导致补体结合抗体和沉淀抗体的产生：这些抗体与相应的组织制剂发生反应，但未显示交叉反应。在正常犬类血清或仅接种弗氏佐剂的对照犬类血清中未检测到抗体。通过电子显微镜对甲状旁腺进行研究，为正常犬类和甲状旁腺功能减退症犬类中甲状旁腺激素的分泌和合成机制提供了信息。
