非实质大鼠肝细胞对黏脂贮积症II型和III型成纤维细胞切片中β-N-乙酰氨基葡萄糖苷酶的内吞作用。
Endocytosis of beta-N-acetylglucosaminidase from sections of mucolipidosis-II and-III fibroblasts by non-parenchymal rat liver cells.
作者信息
Ullrich K, von Figura K
出版信息
Biochem J. 1979 Jul 15;182(1):245-7. doi: 10.1042/bj1820245.
Abstract
beta-N-Acetylglucosaminidase isolated from the secretions of fibroblasts of mucolipidosis-II and -III patients is internalized by cultured non-parenchymal rat liver cells. The rate of endocytosis compared with that of beta-N-acetylglucosaminidase from control fibroblasts was 11 and 19% for the enzyme from mucolipidosis-II and -III patients respectively. The inhibition of endocytosis by mannan indicates that the beta-N-acetylglucosaminidase from mucolipidosis-II and -III patients is recognized by cell-surface receptors specific for mannose.
摘要
从黏脂贮积症II型和III型患者成纤维细胞分泌物中分离出的β-N-乙酰氨基葡萄糖苷酶被培养的大鼠非实质肝细胞内化。与来自对照成纤维细胞的β-N-乙酰氨基葡萄糖苷酶相比，黏脂贮积症II型和III型患者的该酶内吞率分别为11%和19%。甘露聚糖对内吞作用的抑制表明，黏脂贮积症II型和III型患者的β-N-乙酰氨基葡萄糖苷酶被对甘露糖具有特异性的细胞表面受体识别。
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2
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Biochem Biophys Res Commun. 1974 Mar 15;57(1):55-61. doi: 10.1016/s0006-291x(74)80356-6.
3
4
A hypothesis for I-cell disease: defective hydrolases that do not enter lysosomes.关于I-细胞病的一种假说：有缺陷的水解酶无法进入溶酶体。
Biochem Biophys Res Commun. 1972 Nov 15;49(4):992-9. doi: 10.1016/0006-291x(72)90310-5.
5
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6
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J Pediatr. 1971 Sep;79(3):366-78. doi: 10.1016/s0022-3476(71)80143-9.
7
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8
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