Hunter R, Blackwood W, Bull J
Br Med J. 1968 Jul 6;3(5609):9-16. doi: 10.1136/bmj.3.5609.9.
The clinical presentation of three patients with meningiomas at different frontal sites is described. They had been ill for 3, 25, and 43 years before the tumour was demonstrated radiologically. Apathy, incontinence, dementia, and fits were seen in association with middle and superior frontal lesions, and may be mistaken for symptoms of involutional depression or presenile cerebral atrophy. In contrast, excitement and hallucinosis were seen in association with a basal frontal lesion, and may mimic psychotic syndromes like hypomania and schizophrenia, particularly if the tumour encroaches on the third ventricle and adjacent structures. Irreversible loss of myelin and axons in the frontal areas of brain surrounding the tumour may have contributed to the clinical picture of the syndrome shown by these patients.
本文描述了三名不同额叶部位患有脑膜瘤患者的临床表现。在肿瘤经放射学检查确诊之前，他们分别患病3年、25年和43年。淡漠、失禁、痴呆和癫痫发作与额叶中部和上部病变相关，可能会被误诊为更年期抑郁症或早老性脑萎缩的症状。相比之下，兴奋和幻觉与额叶底部病变相关，可能会模仿轻躁狂和精神分裂症等精神综合征，特别是当肿瘤侵犯第三脑室和相邻结构时。肿瘤周围额叶区域不可逆的髓鞘和轴突丧失可能导致了这些患者所表现出的综合征的临床症状。
