[关于青霉素的生物合成。产黄青霉菌丝体匀浆和无细胞提取物对苯乙酸和苯氧乙酸的酶促活化以及由6-氨基青霉烷酸和活化侧链酸形成青霉素的研究] - Suppr

[On the biosynthesis of penicillin. Studies on the enzymatic activation of phenylacetic acid and phenoxyacetic acid as well as the formation of penicillin from 6-aminopenicillanic acid and activated side chain acids by mycelial homogenates and cell-free extracts of Penicillium chrysogenum].

作者信息

Brunner R, Röhr M, Zinner M

出版信息

Hoppe Seylers Z Physiol Chem. 1968 Jan;349(1):95-103. doi: 10.1515/bchm2.1968.349.1.95.

DOI:10.1515/bchm2.1968.349.1.95

PMID:4969964

Abstract

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[On the biosynthesis of penicillin. Studies on the enzymatic activation of phenylacetic acid and phenoxyacetic acid as well as the formation of penicillin from 6-aminopenicillanic acid and activated side chain acids by mycelial homogenates and cell-free extracts of Penicillium chrysogenum].

Hoppe Seylers Z Physiol Chem. 1968 Jan;349(1):95-103. doi: 10.1515/bchm2.1968.349.1.95.

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Uptake of phenylacetic acid by Penicillium chrysogenum Wis 54-1255: a critical regulatory point in benzylpenicillin biosynthesis.

J Antibiot (Tokyo). 1989 Sep;42(9):1398-409. doi: 10.7164/antibiotics.42.1398.

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Penicillin productivity and glutathione-dependent detoxification of phenylacetic and phenoxyacetic acids in Penicillium chrysogenum.

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Molecular regulation of beta-lactam biosynthesis in filamentous fungi.

Microbiol Mol Biol Rev. 1998 Sep;62(3):547-85. doi: 10.1128/MMBR.62.3.547-585.1998.

Uptake of phenoxyacetic acid by Penicillium chrysogenum.

Appl Microbiol Biotechnol. 1995 Mar;42(6):945-50. doi: 10.1007/BF00191195.

Utilization of side-chain precursors for penicillin biosynthesis in a high-producing strain of Penicillium chrysogenum.

Appl Microbiol Biotechnol. 1994 Feb;40(6):883-7. doi: 10.1007/BF00173993.

Specificity of penicillin acylase of Fusarium and of Penicillium chrysogenum.

Appl Microbiol. 1968 Oct;16(10):1557-63. doi: 10.1128/am.16.10.1557-1563.1968.

Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum.

Antimicrob Agents Chemother. 1987 Nov;31(11):1675-82. doi: 10.1128/AAC.31.11.1675.

Behaviour of tritium-labelled isopenicillin N and 6-aminopenicillanic acid as potential penicillin precursors in an extract of Penicillum chrysogenum.

Biochem J. 1975 Dec;151(3):741-6. doi: 10.1042/bj1510741.

Biosynthesis of aflatoxins.

Bacteriol Rev. 1977 Dec;41(4):822-55. doi: 10.1128/br.41.4.822-855.1977.

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[On the biosynthesis of penicillin. Studies on the enzymatic activation of phenylacetic acid and phenoxyacetic acid as well as the formation of penicillin from 6-aminopenicillanic acid and activated side chain acids by mycelial homogenates and cell-free extracts of Penicillium chrysogenum].

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[On the biosynthesis of penicillin. Studies on the enzymatic activation of phenylacetic acid and phenoxyacetic acid as well as the formation of penicillin from 6-aminopenicillanic acid and activated side chain acids by mycelial homogenates and cell-free extracts of Penicillium chrysogenum].

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