Wagner W D
Atherosclerosis. 1979 Sep;34(1):1-11. doi: 10.1016/0021-9150(79)90100-x.
The aortic content of glycopeptide sialic acid, hexosamine and hexose was studied in a genetically selected strain of White Carneau pigeons (WC-2) with significantly more severe atherosclerosis than randomly bred White Carneau pigeons (RBWC). Pigeons were fed an atherogenic diet for 3 months and examined to determine differences in content of glycopeptide-sugars between WC-2 and RBWC, changes with the progression of atherosclerosis and the relationship of aortic cholesterol to glycopeptide-sugar content. In animals with mainly normal aorta (cholesterol content of 0.2-0.3 mg/cm2-aorta) sialic acid was significantly lower in WC-2 pigeons. The progression of atherosclerosis was associated with increased aortic glycopeptide sialic acid (r = 0.78; p less than 0.05) in WC-2 pigeons whereas an inverse relationship was suggested in RBWC pigeons. In WC-2, but not RBWC pigeons, significant positive relationships were seen for aortic glycopeptide hexosamine and aortic cholesterol and for aortic glycopeptide hexose and aortic cholesterol. The findings implicate a possible role of aortic glycoproteins in either the initiation or modulation of atherosclerosis of the WC-2 pigeon.
对遗传选育的白卡诺鸽品系（WC - 2）的主动脉糖肽唾液酸、己糖胺和己糖含量进行了研究，该品系的动脉粥样硬化比随机繁殖的白卡诺鸽（RBWC）严重得多。给鸽子喂食致动脉粥样化饮食3个月，并进行检查，以确定WC - 2和RBWC之间糖肽糖含量的差异、动脉粥样硬化进展过程中的变化以及主动脉胆固醇与糖肽糖含量的关系。在主动脉主要正常（胆固醇含量为0.2 - 0.3 mg/cm² - 主动脉）的动物中，WC - 2鸽的唾液酸显著较低。在WC - 2鸽中，动脉粥样硬化的进展与主动脉糖肽唾液酸增加相关（r = 0.78；p < 0.05），而在RBWC鸽中则显示出相反的关系。在WC - 2鸽而非RBWC鸽中，观察到主动脉糖肽己糖胺与主动脉胆固醇以及主动脉糖肽己糖与主动脉胆固醇之间存在显著的正相关关系。这些发现表明主动脉糖蛋白在WC - 2鸽动脉粥样硬化的起始或调节中可能发挥作用。
