芬太尼的药代动力学可能是呼吸抑制复发的一个解释。

Pharmacokinetics of fentanyl as a possible explanation for recurrence of respiratory depression.

作者信息

Stoeckel H, Hengstmann J H, Schüttler J

出版信息

Br J Anaesth. 1979 Aug;51(8):741-5. doi: 10.1093/bja/51.8.741.

DOI:10.1093/bja/51.8.741

Abstract

The pharmacokinetics of fentanyl are complicated by an additional increase in plasma concentration during the elimination phase of the drug. We have confirmed that fentanyl is excreted in the gastric juice and reabsorbed from the alkaline medium of the small intestine. In addition, the stomach wall in rats has an important storage capacity for fentanyl. A maximum of about 20% of the dose was found in the stomach wall after i.v. injection. In man the resected part of the stomach contained 16% of the dose, 10 min after injection. These observations could be important in explaining the occurrence of respiratory depression in the period after operation.

摘要

芬太尼的药代动力学因药物消除阶段血浆浓度的额外升高而变得复杂。我们已经证实，芬太尼可经胃液排泄，并从小肠碱性介质中重新吸收。此外，大鼠的胃壁对芬太尼具有重要的储存能力。静脉注射后，在胃壁中发现的剂量最高约为给药量的20%。在人体中，注射后10分钟，切除的胃部分含有给药量的16%。这些观察结果对于解释术后呼吸抑制的发生可能具有重要意义。