一种使用琥珀酰胆碱诱导经咖啡因处理的肌肉挛缩来检测恶性高热表型的筛查试验及其被丹曲林抑制的情况。
A screening test for the malignant hyperpyrexia phenotype using suxamethonium-induced contracture of muscle treated with caffeine and its inhibition by dantrolene.
作者信息
Halsall P J, Ellis F R
出版信息
Br J Anaesth. 1979 Aug;51(8):753-6. doi: 10.1093/bja/51.8.753.
PMID:497072
Abstract
Suxamethonium induced a contracture in caffeine pretreated human muscle in vitro. The contracture was significantly greater (P less than 0.001) with MHS muscle compared with muscle from normal subjects. This reaction is now used as an additional screening test for the MHS phenotype. The contracture was prevented by pretreatment with dantrolene.
摘要
琥珀酰胆碱在体外可使经咖啡因预处理的人体肌肉发生挛缩。与正常受试者的肌肉相比，MHS（恶性高热易感）肌肉的挛缩程度显著更严重（P小于0.001）。这种反应现在被用作MHS表型的一种额外筛查试验。丹曲林预处理可预防挛缩。
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