• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种使用琥珀酰胆碱诱导经咖啡因处理的肌肉挛缩来检测恶性高热表型的筛查试验及其被丹曲林抑制的情况。

A screening test for the malignant hyperpyrexia phenotype using suxamethonium-induced contracture of muscle treated with caffeine and its inhibition by dantrolene.

作者信息

Halsall P J, Ellis F R

出版信息

Br J Anaesth. 1979 Aug;51(8):753-6. doi: 10.1093/bja/51.8.753.

DOI:10.1093/bja/51.8.753
PMID:497072
Abstract

Suxamethonium induced a contracture in caffeine pretreated human muscle in vitro. The contracture was significantly greater (P less than 0.001) with MHS muscle compared with muscle from normal subjects. This reaction is now used as an additional screening test for the MHS phenotype. The contracture was prevented by pretreatment with dantrolene.

摘要

琥珀酰胆碱在体外可使经咖啡因预处理的人体肌肉发生挛缩。与正常受试者的肌肉相比，MHS（恶性高热易感）肌肉的挛缩程度显著更严重（P小于0.001）。这种反应现在被用作MHS表型的一种额外筛查试验。丹曲林预处理可预防挛缩。

相似文献

1
A screening test for the malignant hyperpyrexia phenotype using suxamethonium-induced contracture of muscle treated with caffeine and its inhibition by dantrolene.一种使用琥珀酰胆碱诱导经咖啡因处理的肌肉挛缩来检测恶性高热表型的筛查试验及其被丹曲林抑制的情况。
Br J Anaesth. 1979 Aug;51(8):753-6. doi: 10.1093/bja/51.8.753.
2
Does prior dantrolene affect the in vitro diagnosis of malignant hyperthermia susceptibility?
Can Anaesth Soc J. 1979 Nov;26(6):484-8. doi: 10.1007/BF03006162.
3
Dantrolene and caffeine contracture test.丹曲林和咖啡因挛缩试验。
Can Anaesth Soc J. 1980 May;27(3):303-4.
4
Dantrolene and caffeine contracture test.
Can Anaesth Soc J. 1980 May;27(3):304-5.
5
Studies on normal human skeletal muscle in relation to the pathopharmacology of malignant hyperpyrexia.
Clin Exp Pharmacol Physiol. 1977 May-Jun;4(3):315-22. doi: 10.1111/j.1440-1681.1977.tb02628.x.
6
[Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients].[对氯间甲酚与咖啡因对恶性高热易感患者肌肉挛缩的影响]
Harefuah. 1997 Jun 15;132(12):839-41, 911.
7
Attenuation of serotonin-induced contractures in skeletal muscle from malignant hyperthermia-susceptible patients with dantrolene.用丹曲林减轻恶性高热易感患者骨骼肌中5-羟色胺诱导的挛缩。
Acta Anaesthesiol Scand. 1997 Nov;41(10):1312-8. doi: 10.1111/j.1399-6576.1997.tb04650.x.
8
[In vitro diagnosis of malignant hyperpyrexia syndrome].[恶性高热综合征的体外诊断]
Harefuah. 1991 Dec 15;121(12):499-502.
9
Effect of diltiazem and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible porcine skeletal muscle.
Br J Anaesth. 1989 May;62(5):566-72. doi: 10.1093/bja/62.5.566.
10
Screening for malignant hyperpyrexia.
Br J Anaesth. 1977 Feb;49(2):169-72. doi: 10.1093/bja/49.2.169.

引用本文的文献

1
Clinical, morphological and genetic characterization of Brody disease: an international study of 40 patients.布罗迪病的临床、形态学和遗传学特征：40 例患者的国际研究。
Brain. 2020 Feb 1;143(2):452-466. doi: 10.1093/brain/awz410.
2
Functional and genetic characterization of clinical malignant hyperthermia crises: a multi-centre study.临床恶性高热危象的功能与遗传学特征：一项多中心研究
Orphanet J Rare Dis. 2014 Jan 16;9:8. doi: 10.1186/1750-1172-9-8.
3
Dantrolene.丹曲林
Can Anaesth Soc J. 1984 Jan;31(1):61-75. doi: 10.1007/BF03011484.
4
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.丹曲林。对其药效学、药代动力学特性以及在恶性高热、抗精神病药物恶性综合征中的治疗用途的综述，并更新其在肌肉痉挛中的应用。
Drugs. 1986 Aug;32(2):130-68. doi: 10.2165/00003495-198632020-00003.