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氟哌利多有阿托品样作用吗?

Has droperidol an atropinic effect?

作者信息

Parmentier P, Dagnelie P

出版信息

Br J Anaesth. 1979 Aug;51(8):775-8. doi: 10.1093/bja/51.8.775.

Abstract

The action of droperidol on the tachycardia produced by atropine and on the serum concentration of cholinesterases was observed during balanced anaesthesia. Without atropine, the mean heart rates of patients who received fentanyl plus droperidol were similar. Atropine increased heart rate only in the presence of droperidol (P less than 0.001) (fentanyl v. fentanyl plus droperidol: P less than 0.05). Droperidol inhibited serum cholinesterases (P less than 0.05); this effect was independent of atropine.

摘要

在平衡麻醉期间,观察了氟哌利多对阿托品所致心动过速以及对血清胆碱酯酶浓度的作用。在未使用阿托品的情况下,接受芬太尼加氟哌利多的患者平均心率相似。阿托品仅在有氟哌利多存在时才会增加心率(P<0.001)(芬太尼与芬太尼加氟哌利多比较:P<0.05)。氟哌利多可抑制血清胆碱酯酶(P<0.05);此效应与阿托品无关。

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