脂肪酸对灌注大鼠心脏摄取甲状腺素的影响。
The effect of fatty acid on the uptake of thyroxine by the perfused rat heart.
作者信息
Hillier A P
出版信息
J Physiol. 1968 Nov;199(1):169-75. doi: 10.1113/jphysiol.1968.sp008646.
Abstract
- A study has been made of the effect of fatty acids on the uptake of thyroxine by the perfused rat heart.2. Oleic acid increases the thyroxine uptake of hearts perfused by solutions containing serum. In the absence of serum, oleic acid is without action.3. The thyroxine uptake of hearts perfused by 0.25% serum is approximately doubled by the addition of oleic acid at a concentration of 0.0025 m-equiv/l. An effect on thyroxine uptake, however, is demonstrable at only one twentieth of this concentration.4. Long-chain fatty acids are much more effective than short-chain fatty acids.
摘要
- 已对脂肪酸对灌注大鼠心脏摄取甲状腺素的影响进行了研究。2. 油酸可增加由含血清溶液灌注的心脏对甲状腺素的摄取。在无血清的情况下，油酸无作用。3. 向含0.25%血清的灌注心脏溶液中添加浓度为0.0025毫当量/升的油酸，可使甲状腺素摄取量增加约一倍。然而，仅在该浓度的二十分之一时，对甲状腺素摄取的影响就可显现。4. 长链脂肪酸比短链脂肪酸有效得多。
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