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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Myasishcheva N V, Quadros E V, Matthews D M, Linnell J C

Biochim Biophys Acta. 1979 Nov 15;588(1):81-8. doi: 10.1016/0304-4165(79)90373-8.

72 h uptake of cyano[57Co]cobalamin and formation of 57Co-labelled methylcobalamin, adenosylcobalamin and hydroxocobalamin has been estimated with and without the addition of methylcobalamin analogues in phytohaemagglutinin-stimulated lymphocytes from healthy human subjects. 2. Difluorochloromethylcobalamin reduced cell uptake of cyanocobalamin and caused a disproportionate reduction in synthesis of adenosylcobalamin. 3. Methylcobalamin-palladium trichloride reduced cell uptake of cyanobalamin more effectively than did difluorochloromethylcobalamin and reduced the formation of methylcobalamin, adenosylcobalamin and hydroxocobalamin in proportion. 4. The results suggest that in addition to inhibiting uptake of cyanocobalamin, one or both compounds may have interfered directly with the mechanism of synthesis of the cobalamin coenzymes.

在有或没有添加甲基钴胺类似物的情况下，已对来自健康人类受试者的植物血凝素刺激淋巴细胞中氰基[57Co]钴胺素的72小时摄取以及57Co标记的甲基钴胺素、腺苷钴胺素和羟钴胺素的形成进行了评估。2. 二氟氯甲基钴胺素降低了细胞对氰钴胺素的摄取，并导致腺苷钴胺素合成的不成比例减少。3. 三氯化钯甲基钴胺素比二氟氯甲基钴胺素更有效地降低了细胞对氰钴胺素的摄取，并按比例减少了甲基钴胺素、腺苷钴胺素和羟钴胺素的形成。4. 结果表明，除了抑制氰钴胺素的摄取外，这两种化合物中的一种或两种可能直接干扰了钴胺素辅酶的合成机制。

Myasishcheva N V, Quadros E V, Matthews D M, Linnell J C

Biochim Biophys Acta. 1979 Nov 15;588(1):81-8. doi: 10.1016/0304-4165(79)90373-8.

72 h uptake of cyano[57Co]cobalamin and formation of 57Co-labelled methylcobalamin, adenosylcobalamin and hydroxocobalamin has been estimated with and without the addition of methylcobalamin analogues in phytohaemagglutinin-stimulated lymphocytes from healthy human subjects. 2. Difluorochloromethylcobalamin reduced cell uptake of cyanocobalamin and caused a disproportionate reduction in synthesis of adenosylcobalamin. 3. Methylcobalamin-palladium trichloride reduced cell uptake of cyanobalamin more effectively than did difluorochloromethylcobalamin and reduced the formation of methylcobalamin, adenosylcobalamin and hydroxocobalamin in proportion. 4. The results suggest that in addition to inhibiting uptake of cyanocobalamin, one or both compounds may have interfered directly with the mechanism of synthesis of the cobalamin coenzymes.

在有或没有添加甲基钴胺类似物的情况下，已对来自健康人类受试者的植物血凝素刺激淋巴细胞中氰基[57Co]钴胺素的72小时摄取以及57Co标记的甲基钴胺素、腺苷钴胺素和羟钴胺素的形成进行了评估。2. 二氟氯甲基钴胺素降低了细胞对氰钴胺素的摄取，并导致腺苷钴胺素合成的不成比例减少。3. 三氯化钯甲基钴胺素比二氟氯甲基钴胺素更有效地降低了细胞对氰钴胺素的摄取，并按比例减少了甲基钴胺素、腺苷钴胺素和羟钴胺素的形成。4. 结果表明，除了抑制氰钴胺素的摄取外，这两种化合物中的一种或两种可能直接干扰了钴胺素辅酶的合成机制。