大鼠后肢5-羟色胺受体的某些特性
Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat.
作者信息
Cooper M, Wyllie J H
出版信息
Br J Pharmacol. 1979 Sep;67(1):79-85.
Abstract
1 The rat hindquarter preparation, as described, responds with reproducible vasoconstriction to noradrenaline and tryptamines. 2 The receptors involved in these responses are distinct. 3 Evidence of heterogeneity of tryptamine receptors was not obtained. 4 The 5-hydroxytryptamine (5-HT) antagonists, methysergide and cyproheptadine, although very potent, displayed antagonism of a non-competitive type whereas a series of phenothiazines and phentolamine displayed competitive antagonism against 5-HT. 5 For the phenothiazines the order of increasing potency was promazine less than chlorpromazine less than triflupromazine.
摘要
- 如所述，大鼠后肢标本对去甲肾上腺素和色胺会产生可重复的血管收缩反应。2. 参与这些反应的受体是不同的。3. 未获得色胺受体异质性的证据。4. 5-羟色胺（5-HT）拮抗剂麦角酰二乙胺和赛庚啶虽然效力很强，但表现出非竞争性拮抗作用，而一系列吩噻嗪类药物和酚妥拉明则对5-HT表现出竞争性拮抗作用。5. 对于吩噻嗪类药物，效力增强的顺序为：异丙嗪＜氯丙嗪＜三氟拉嗪。
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Two types of excitatory receptor for 5-hydroxytryptamine in dog vasculature? [proceedings].犬血管系统中5-羟色胺的两种兴奋性受体？[会议论文集]
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