吡啶醛肟肠道吸收的体外研究。
An in vitro study of the intestinal absorption of pyridinium aldoximes.
作者信息
Crone H D, Keen T E
出版信息
Br J Pharmacol. 1969 Feb;35(2):304-12. doi: 10.1111/j.1476-5381.1969.tb07989.x.
Abstract
- The transfer rates of three pyridinium aldoximes, a non-quaternary pyridine aldoxime and choline across the wall of sacs from the jejunum of rats were measured in vitro.2. The transfer rates observed for any one of the quaternary compounds could be inversely correlated with the transmural potential of the particular sac studied, but there was no correlation with the rates of water or glucose transfer.3. 2-hydroxyiminomethyl-N-methylpyridinium iodide (PAM) had a transfer rate seven times less than that of its non-quaternary analogue, 2-hydroxyiminomethyl pyridine.4. Neither neostigmine nor EDTA affected the transfer rate of PAM in the conditions used.5. It was concluded that the transfer of the quaternary compounds could be explained by diffusion through aqueous pores.
摘要
在体外测量了三种吡啶醛肟、一种非季铵化吡啶醛肟和胆碱通过大鼠空肠囊壁的转运速率。
观察到的任何一种季铵化合物的转运速率都可能与所研究的特定囊的跨膜电位呈负相关，但与水或葡萄糖的转运速率无关。
2-羟基亚胺甲基-N-甲基碘化吡啶（PAM）的转运速率比其非季铵类似物2-羟基亚胺甲基吡啶低七倍。
在所用条件下，新斯的明和乙二胺四乙酸（EDTA）均未影响PAM的转运速率。
得出的结论是，季铵化合物的转运可以通过通过水孔的扩散来解释。
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