Smith L, Parnsingha T
Thorax. 1969 Jul;24(4):457-60. doi: 10.1136/thx.24.4.457.
In an attempt to improve both the resectability and survival rates for bronchogenic carcinoma, pre-operative supervoltage radiotherapy was introduced in 1961 and continued for a period of three years. Patients with either a histological or cytological diagnosis were given a tumour dose of 4,500 r over six weeks and then a two-month period elapsed before surgery. A follow-up of cases treated during the period revealed a five-year survival rate of 15·7%. This rate is low when compared with the results achieved at this hospital with surgery alone. This finding is attributed to the harmful effects of radiotherapy which have led to a high bronchopleural fistula rate of 15·5%. A single case of myocardial radionecrosis also occurred. No improvement is noted in the resectability rate. An overall assessment is that radiotherapy has provided no benefits but has in fact greatly increased both the morbidity and mortality rates.
为提高支气管源性癌的切除率和生存率，1961年引入了术前超高压放疗，并持续了三年。组织学或细胞学确诊的患者在六周内接受4500拉德的肿瘤剂量照射，然后在手术前间隔两个月。对该期间治疗的病例进行随访发现，五年生存率为15.7%。与本院单纯手术的结果相比，该比率较低。这一发现归因于放疗的有害影响，导致支气管胸膜瘘发生率高达15.5%。还发生了一例心肌放射性坏死。切除率未见提高。总体评估是，放疗没有带来益处，反而实际上大大增加了发病率和死亡率。
