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可传播给实验动物的中枢神经系统退行性疾病

Degenerative diseases of the central nervous system transmissible to experimental animals.

作者信息

Beck E, Daniel P M

出版信息

Postgrad Med J. 1969 Jun;45(524):361-70. doi: 10.1136/pgmj.45.524.361.

DOI:10.1136/pgmj.45.524.361
PMID:4979006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2466714/
Abstract

The clinical features and the pathological changes in the central nervous system of scrapie and kuru are described and attention is drawn to the similarities between these conditions. In both, inoculation of tissues into experimental animals reproduces a similar disease after a prolonged latent period. The transmission of subacute presenile polioencephalopathy to a chimpanzee is noted. The work which led to the discovery of the transmissibility of these conditions is mentioned.

摘要

描述了羊瘙痒症和库鲁病中枢神经系统的临床特征及病理变化，并提请注意这些病症之间的相似之处。在这两种病症中，将组织接种到实验动物体内，经过一段漫长的潜伏期后会引发类似的疾病。还提到了亚急性早老性脑灰质炎向黑猩猩的传播。文中提及了导致发现这些病症具有传染性的研究工作。

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相似文献

1
Degenerative diseases of the central nervous system transmissible to experimental animals.可传播给实验动物的中枢神经系统退行性疾病
Postgrad Med J. 1969 Jun;45(524):361-70. doi: 10.1136/pgmj.45.524.361.
2
Transmissible degenerative diseases of the nervous system.神经系统可传播性退行性疾病。
Proc R Soc Med. 1971 Jul;64(7):787-94. doi: 10.1177/003591577106400736.
3
Subacute spongiform virus encephalopathies. Scrapie, Kuru and Creutzfeldt-Jakob disease: a review.亚急性海绵状病毒脑病。羊瘙痒病、库鲁病和克雅氏病：综述。
Am J Pathol. 1972 Sep;68(3):626-52.
4
Neuropathological comparisons of experimental kuru in chimpanzees with human kuru.
Int Arch Allergy Appl Immunol. 1969;36:Suppl:553-62.
5
[Encephalopathy caused by prions].[朊病毒所致脑病]
Rev Neurol (Paris). 1990;146(1):1-11.
6
Pathogenesis of subacute spongiform encephalopathies.亚急性海绵状脑病的发病机制。
Ann Clin Lab Sci. 1976 Jan-Feb;6(1):84-103.
7
Status spongiosus of nervous tissue. Electron microscopic studies.神经组织的海绵状状态。电子显微镜研究。
Acta Neuropathol. 1971;19(4):271-89. doi: 10.1007/BF00692148.
8
Prion diseases of the central nervous system.中枢神经系统的朊病毒病。
Monogr Pathol. 1990(32):86-122.
9
[Prions].
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1988 Apr-Jun;33(2):117-32.
10
Search for infectious etiology in chronic and subacute degenerative diseases of the central nervous system.
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引用本文的文献

1
Virological aspects of neurological disease.神经疾病的病毒学方面
Postgrad Med J. 1969 Jun;45(524):351-60. doi: 10.1136/pgmj.45.524.351.
2
Transmissible slow diseases.
Ir J Med Sci. 1973 Jan;142(1):27-34. doi: 10.1007/BF02949986.
3
Creutzfeldt-Jakob disease. Some unusual morphological features reminiscent of kuru.
Z Neurol. 1973 Dec 31;206(1):1-24.

本文引用的文献

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An experimental study of post mortem alterations in neurons of the central nervous system.中枢神经系统神经元死后变化的实验研究。
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AN ATAXIC FORM OF SUBACUTE PRESENILE POLIOENCEPHALOPATHY (CREUTZFELDT-JAKOB DISEASE).一种亚急性早老性脑脊髓病（克雅氏病）的共济失调型
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DEGENERATION OF THE CEREBELLAR AND HYPOTHALAMONEUROHYPOPHYSIAL SYSTEMS IN SHEEP WITH SCRAPIE; AND ITS RELATIONSHIP TO HUMAN SYSTEM DEGENERATIONS.患瘙痒病绵羊的小脑和下丘脑神经垂体系统的退化；及其与人类系统退化的关系。
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Kuru.库鲁病
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Subacute spongiform encephalopathy--a subacute form of encephalopathy attributable to vascular dysfunction (spongiform cerebral atrophy).亚急性海绵状脑病——一种由血管功能障碍引起的亚急性脑病形式（海绵状脑萎缩）。
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