Unruh H, Robertson D I, Karasewich E
Can J Surg. 1979 Nov;22(6):586-90.
The clinical features are presented of three patients in whom lymphangiosarcoma developed after radical mastectomy followed by local irradiation. The median time between radical mastectomy and the diagnosis by biopsy of lymphangiosarcoma was 9.9 years. No form of therapy, including high-dose combination chemotherapy, appeared able to control the disease. All three patients died with residual lymphangiosarcoma and in two it was the direct cause of death. These results stress that prevention of postmastectomy lymphangiosarcoma is vital. This can be accomplished by avoiding radical mastectomy followed by local irradiation. Ultrastructural observations in one case suggest that the tumour has a primitive vasoformative origin.
本文介绍了三例患者的临床特征，这三例患者在根治性乳房切除术后接受局部放疗后发生了淋巴管肉瘤。根治性乳房切除术与经活检诊断为淋巴管肉瘤之间的中位时间为9.9年。包括大剂量联合化疗在内的任何治疗方式似乎都无法控制该疾病。所有三名患者均死于残留的淋巴管肉瘤，其中两名患者的直接死因是淋巴管肉瘤。这些结果强调了预防乳房切除术后淋巴管肉瘤至关重要。这可以通过避免根治性乳房切除术后进行局部放疗来实现。对其中一例的超微结构观察表明，该肿瘤起源于原始的血管形成。
