马立克氏病疱疹型病毒（HPRS - 16株）在细胞培养传代过程中致瘤性丧失及毒力减弱。 - Suppr

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超能文献

The attenuation, with loss of oncogenicity, of the herpes-type virus of Marek's disease (strain HPRS-16) on passage in cell culture.

作者信息

Churchill A E, Chubb R C, Baxendale W

出版信息

J Gen Virol. 1969 Jun;4(4):557-64. doi: 10.1099/0022-1317-4-4-557.

DOI:10.1099/0022-1317-4-4-557

PMID:4979519

Abstract

摘要

相似文献

The attenuation, with loss of oncogenicity, of the herpes-type virus of Marek's disease (strain HPRS-16) on passage in cell culture.马立克氏病疱疹型病毒（HPRS - 16株）在细胞培养传代过程中致瘤性丧失及毒力减弱。

J Gen Virol. 1969 Jun;4(4):557-64. doi: 10.1099/0022-1317-4-4-557.

Isolation of herpes type virus from chickens with Marek's disease using duck embryo fibroblast cultures.利用鸭胚成纤维细胞培养物从患马立克氏病的鸡中分离疱疹病毒。

Biken J. 1970 Sep;13(3):193-203.

Demonstration of a herpes-type virus in short-term cultured blood lymphocytes associated with Marek's disease.在与马立克氏病相关的短期培养血液淋巴细胞中发现一种疱疹型病毒。

J Med Microbiol. 1970 Aug;3(3):463-73. doi: 10.1099/00222615-3-3-463.

Propagation of herpes type virus isolated from chickens with Marek's disease in Japanese quail embryo fibroblasts.从患有马立克氏病的鸡中分离出的疱疹病毒在日本鹌鹑胚胎成纤维细胞中的增殖。

Biken J. 1970 Sep;13(3):219-28.

Comparison of cytopathic effects of a classical isolate of Marek's disease virus in cell cultures of duck embryo fibroblasts and chicken kidney.马立克氏病病毒经典毒株在鸭胚成纤维细胞和鸡肾细胞培养物中的细胞病变效应比较

Avian Dis. 1972 Jan-Mar;16(2):291-307.

Lack of pathogenicity of Marek's disease virus and herpesvirus of turkeys in marmoset monkeys.马立克氏病病毒和火鸡疱疹病毒在狨猴中的致病性缺失

J Natl Cancer Inst. 1972 Oct;49(4):1191-7.

[Study of the properties of the cytopathogenic agent isolated in tissue cultures from the poultry with signs of Marek's disease].[对从患有马立克氏病症状的家禽组织培养物中分离出的细胞致病因子特性的研究]

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Acute Marek's disease: isolation of a cytopathogenic agent in cell culture.急性马立克氏病：在细胞培养中分离出一种细胞致病因子。

Aust Vet J. 1970 Dec;46(12):587-94. doi: 10.1111/j.1751-0813.1970.tb06663.x.

Marek's disease herpesvirus: in vivo and in vitro infection of kidney cells of different genetic strains of chickens.马立克氏病疱疹病毒：对不同遗传品系鸡肾细胞的体内和体外感染

Avian Dis. 1969 Nov;13(4):753-61.

Propagation and behavior in chicken kidney cultures of the agent associated with classical Marek's disease.与经典马立克氏病相关病原体在鸡肾培养物中的增殖与行为

J Natl Cancer Inst. 1969 Oct;43(4):907-16.

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Characterizing the molecular basis of attenuation of Marek's disease virus via in vitro serial passage identifies de novo mutations in the helicase-primase subunit gene UL5 and other candidates associated with reduced virulence.通过体外连续传代鉴定马立克氏病病毒减毒的分子基础，发现了在解旋酶-引发酶亚基基因 UL5 中出现的新突变和其他与毒力降低相关的候选基因。

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Marek's disease virus expresses multiple UL44 (gC) variants through mRNA splicing that are all required for efficient horizontal transmission.马立克氏病病毒通过 mRNA 剪接表达多种 UL44（gC）变体，这些变体都需要有效地水平传播。

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Revaccination with Marek's disease vaccines induces productive infection and superior immunity.用马立克氏病疫苗再次接种可引发增殖性感染并产生更强的免疫力。

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