Schwartz R A, Burgess G H, Milgrom H
Cancer. 1979 Nov;44(5):1601-5. doi: 10.1002/1097-0142(197911)44:5<1601::aid-cncr2820440510>3.0.co;2-8.
We report a 60-year-old woman with a history of x-ray therapy for generalized hirsutism at 20 years of age who at the age of 37 years developed the first of numerous basal cell epitheliomas on her trunk, including chest, on a background of radiation damaged skin. At the age of 51 years one of the basal cell epitheliomas was biopsied and an incidental histologic finding was a breast carcinoma. The basal cell epithelioma is clearly linked with x-ray exposure; breast cancer is less so although there is impressive epidemiologic evidence supporting an association between human breast cancer and radiation exposure. In view of an association between thyroid cancer and dermatologic x-ray therapy, further investigation of such an association with breast cancer should be considered. It may be wise to evaluate patients who received dermatologic x-ray exposure to their breasts for possible breast cancer and to consider radiation induced skin damage on or near the skin overlying the thyroid or breasts as a cutaneous marker of internal malignancy or potential internal malignancy.
我们报告一名60岁女性，她20岁时因全身性多毛症接受过X线治疗，37岁时在胸部等躯干部位的放射性损伤皮肤上出现了首个多发性基底细胞上皮瘤。51岁时，其中一个基底细胞上皮瘤经活检，偶然发现同时患有乳腺癌。基底细胞上皮瘤与X线照射有明确关联；乳腺癌与之关联较小，不过有令人瞩目的流行病学证据支持人类乳腺癌与辐射暴露之间存在关联。鉴于甲状腺癌与皮肤科X线治疗之间存在关联，应考虑进一步研究其与乳腺癌的这种关联。对接受过乳房皮肤X线照射的患者评估是否可能患有乳腺癌，并将甲状腺或乳房上方皮肤或其附近的放射性皮肤损伤视为内部恶性肿瘤或潜在内部恶性肿瘤的皮肤标志物，可能是明智的做法。
