DiStefano A, Yong Yap Y, Hortobagyi G N, Blumenschein G R
Cancer. 1979 Nov;44(5):1913-8. doi: 10.1002/1097-0142(197911)44:5<1913::aid-cncr2820440554>3.0.co;2-d.
One hundred one breast cancer patients with brain metastases (BM) were reviewed. The median survival from BM was 4.0 months. Seventy percent were receiving chemotherapy at the diagnosis of BM and 43% were showing a clinical response. Prolonged survival was seen in patients who underwent surgical resection, those with the brain as site of first metastasis, and those with a long free interval who survived the initial 5 months after BM. Long-term survivors (greater than 18 months from BM) demonstrated indolent disease by all parameters measured.
对101例发生脑转移（BM）的乳腺癌患者进行了回顾性研究。脑转移后的中位生存期为4.0个月。70%的患者在脑转移诊断时正在接受化疗，43%的患者有临床反应。接受手术切除的患者、以脑为首发转移部位的患者以及脑转移后最初5个月存活且无瘤间期较长的患者生存期延长。长期存活者（脑转移后超过18个月）在所有测量参数上均显示疾病进展缓慢。
