[Lipofuscinosis of the liver].

Liver tissue biopsy performed in a man of 44 and another man of 52, who had for long periods of time been using phenacetin-containing analgesics, revealed accumulations of lipofuscin in hepatocytes, in sinoendothelia and in Kupffer's cells. Apart from more frequent destruction of hepatocytes, there were no microscopic or ultrastructural changes suggesting any major liver tissue damage.