头孢孟多在接受血液透析的尿毒症患者中的动力学。

Cefamandole kinetics in uremic patients undergoing hemodialysis.

作者信息

Gambertoglio J G, Aziz N S, Lin E T, Grausz H, Naughton J L, Benet L Z

出版信息

Clin Pharmacol Ther. 1979 Nov;26(5):592-9. doi: 10.1002/cpt1979265592.

DOI:10.1002/cpt1979265592

Abstract

A single intravenous 15 mg/kg dose of cefamandole was given to 6 patients in chronic renal failure before hemodialysis, and 3 were examined during an interdialysis period. Mean cefamandole clearance by hemodialysis was 24 +/- 12 ml/min; 35 +/- 15% of the dose was recovered in the dialysate. The cefamandole half-life (1 1/2) on dialysis was 4.0 +/- 0.29 hr; off dialysis it was 13.9 +/- 4.2 hr. High urine concentrations of cefamandole in these patients suggests usefulness in urinary tract infection.

摘要

在血液透析前，对6例慢性肾衰竭患者静脉注射单剂量15mg/kg的头孢孟多，其中3例在透析间期接受检查。血液透析对头孢孟多的平均清除率为24±12ml/分钟；35±15%的剂量在透析液中回收。透析时头孢孟多的半衰期为4.0±0.29小时；透析间期为13.9±4.2小时。这些患者尿液中头孢孟多的高浓度表明其对尿路感染有效。