Lecaillon J B, Souppart C, Schoeller J P, Humbert G, Massias P
Clin Pharmacol Ther. 1979 Nov;26(5):611-7. doi: 10.1002/cpt1979265611.
Sulfinpyrazone kinetics has been investigated after intravenous and oral doses. They may be described by a 3-compartment open model. In the body about half the drug is in the plasma or in interstitial fluids, which equilibrated with plasma. Most of the rest is in an extravascular compartment, from which it easily diffuses back to the plasma. About 3% of the dose is still in the body after 24 hr and is located mainly in a deep compartment. After oral administration, sulfinpyrazone is quickly absorbed, largely from the stomach.
已对静脉注射和口服剂量后的磺吡酮动力学进行了研究。它们可用三室开放模型来描述。在体内，约一半的药物存在于血浆或与血浆平衡的组织间液中。其余大部分存在于血管外隔室，药物很容易从该隔室扩散回血浆。给药24小时后，约3%的剂量仍存在于体内，主要位于深部隔室。口服给药后，磺吡酮吸收迅速，主要从胃吸收。
