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暴露于枯草芽孢杆菌的蛋白水解酶后仓鼠出现肺出血。

Pulmonary hemorrhage in hamsters after exposure to proteolytic enzymes of Bacillus subtilis.

作者信息

Goldring I P, Ratner I M, Greenburg L

出版信息

Science. 1970 Oct 2;170(3953):73-4. doi: 10.1126/science.170.3953.73.

DOI:10.1126/science.170.3953.73
PMID:4989150
Abstract

Single exposures of Syrian hamsters by aerosol inhalation or intratracheal instillation to proteolytic enzymes of Bacillus subtilis produced massive pulmonary hemorrhage within the first week. Of 46 animals exposed, eight died as a result of extensive hemorrhage. The remainder made uneventful recovery with no apparent residual pulmonary disease 6 weeks after exposure.

摘要

通过气溶胶吸入或气管内滴注对叙利亚仓鼠单次暴露于枯草芽孢杆菌的蛋白水解酶,在第一周内会导致大量肺出血。在46只暴露的动物中,有8只因广泛出血而死亡。其余动物在暴露6周后顺利康复,没有明显的残留肺部疾病。

相似文献

1
Pulmonary hemorrhage in hamsters after exposure to proteolytic enzymes of Bacillus subtilis.暴露于枯草芽孢杆菌的蛋白水解酶后仓鼠出现肺出血。
Science. 1970 Oct 2;170(3953):73-4. doi: 10.1126/science.170.3953.73.
2
Pulmonary disease due to inhalation of derivatives of Bacillus subtilis containing proteolytic enzyme.
Lancet. 1969 Jun 14;1(7607):1177-81. doi: 10.1016/s0140-6736(69)92165-5.
3
[Bronchial asthma following occupational exposure to proteolytic enzymes (Bacillus subtilis proteases)].
Schweiz Med Wochenschr. 1970 Nov 7;100(45):1908-14.
4
Allergic bronchial reactions to inhalation of enzymes of Bacillus subtilis.吸入枯草芽孢杆菌酶引起的变应性支气管反应。
Am Rev Respir Dis. 1973 Mar;107(3):387-94. doi: 10.1164/arrd.1973.107.3.387.
5
A study of workers exposed to detergent enzymes.
JAMA. 1971 Jul 26;217(4):425-33.
6
Clinical, immunologic, and physiologic observations in factory workers exposed to B. subtilis enzyme dust.
J Allergy. 1971 Mar;47(3):170-80. doi: 10.1016/s0091-6749(71)80295-6.
7
Medical problems in the detergent industry caused by proteolytic enzymes from bacillus subtilis.
Acta Allergol. 1972 Feb;27(1):63-86. doi: 10.1111/j.1398-9995.1972.tb01644.x.
8
Papers that have changed the practice of occupational medicine: 'Pulmonary disease due to inhalation of derivatives of Bacillus subtilis containing proteolytic enzyme' by M.L.H. Flindt. 1969.改变职业医学实践的论文:M.L.H. 弗林特所著的《吸入含蛋白水解酶的枯草芽孢杆菌衍生物导致的肺部疾病》,1969年。
Occup Med (Lond). 2002 Feb;52(1):58-63; discussion 57-8. doi: 10.1093/occmed/52.1.56.
9
Respiratory reactions to B. subtilis enzymes in detergents.洗涤剂中枯草芽孢杆菌酶引发的呼吸道反应。
J Occup Med. 1973 Mar;15(3):267-71.
10
Bacillus subtilis enzymes: a 7-year clinical, epidemiological and immunological study of an industrial allergen.枯草芽孢杆菌酶:一种工业过敏原的7年临床、流行病学和免疫学研究
J Soc Occup Med. 1977 Jan;27(1):3-12. doi: 10.1093/occmed/27.1.3.

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