Babichev V N, Samsonova V M
Probl Endokrinol (Mosk). 1975 May-Jun;21(3):68-71.
Experiments were conducted on intact female rats; it was revealed that the content of protein-bound iodine (PBI) in the blood depended on the stage of the estral cycle. It was decreased at the metestrus and diestrus stages. Castration produced an even greater reduction in the blood PBI content. The blood PBI content proved to elevate in administration of estradiol dipropionate (EDP) to castrated rats. The TSH content in the hypophysis increased at the metestrus and diestrus stages and decreased at the proestrus and estrus stages. The relationship was reverse in the case with the blood TTH content. Castration was followed by a marked increase in the TSH content in the hypophysis accompanied by a reduction in the blood hormone level. The TSH concentration in the hypophysis decreased and in the blood increased under the effect of EDP in castrated animals. The data obtained indicated that the interrelationship between the thyroid gland and the sex glands was realized at the level of the hypophysis, and possibly, of the hypothalamus.
对成年雌性大鼠进行了实验；结果显示，血液中蛋白结合碘（PBI）的含量取决于发情周期的阶段。在动情后期和间情期阶段其含量降低。去势导致血液中PBI含量进一步降低。向去势大鼠注射二丙酸雌二醇（EDP）后，血液中PBI含量升高。垂体中促甲状腺激素（TSH）含量在动情后期和间情期阶段升高，而在发情前期和发情期阶段降低。血液中总甲状腺素（TTH）含量的变化情况则相反。去势后垂体中TSH含量显著增加，同时血液中激素水平降低。在去势动物中，EDP作用下垂体中TSH浓度降低而血液中TSH浓度升高。所获得的数据表明，甲状腺与性腺之间的相互关系是在垂体水平，可能还有下丘脑水平实现的。
