Rentrop P, Blanke H, Wiegand V, Karsch K R
Dtsch Med Wochenschr. 1979 Oct 5;104(40):1401-5. doi: 10.1055/s-0028-1129109.
Using guide-wires and special catheters the occluded infarct-related coronary artery was recanalized in 10 patients with acute myocardial infarction 6.6 +/- 7.1 hours after the onset of symptoms. There were no complications. Immediately after recanalization there were 80-95% lesions at the site of the previous occlusion. Angiography, performed in 9 patients in the chronic stage of myocardial infarction, revealed patency of the recanalized vessel in all instances. There was a marked decrease in the narrowing at the time of the second angiogram in 6 patients. Changes in left ventricular function from the acute to the chronic stage were assessed in 8 patients: the ejection fraction increased in 6. The results of this pilot study indicate that transluminal recanalization of acutely occluded coronary arteries is possible without harmful side-effects. Early restoration of flow may salvage the jeopardized myocardium. Further application of this method of treatment in selected patients and efforts to improve the technique seem to be justified.
使用导丝和特殊导管,对10例急性心肌梗死患者在症状发作后6.6±7.1小时闭塞的梗死相关冠状动脉进行了再通。无并发症发生。再通后立即在前闭塞部位有80% - 95%的病变。对9例处于心肌梗死慢性期的患者进行了血管造影,结果显示所有病例中再通血管均通畅。6例患者在第二次血管造影时狭窄程度明显降低。对8例患者评估了从急性期到慢性期左心室功能的变化:6例患者射血分数增加。这项初步研究结果表明,急性闭塞冠状动脉的腔内再通是可行的,且无有害副作用。早期恢复血流可能挽救濒危心肌。在选定患者中进一步应用这种治疗方法并努力改进技术似乎是合理的。