Chihara K, Arimura A, Kubli-Garfias C, Schally A V
Endocrinology. 1979 Dec;105(6):1416-8. doi: 10.1210/endo-105-6-1416.
Electrical stimulation of the preoptic area resulted in a significant increase in the secretion rate of immunoreactive somatostatin (IRS) and its concentration in the hypophysial portal blood of urethane-anesthetized rats. In contrast, stimulation of the ventromedial nucleus did not cause any changes in portal immunoreactive somatostatin. The flow rate of portal blood also increased significantly by electrical stimuli to the preoptic area but not to the ventromedial hypothalamus. These findings support the view that the preoptic area plays an inhibitory role in the regulation of GH secretion by increasing the release of somatostatin into hypophysial portal vessels in the rat.
对乌拉坦麻醉大鼠的视前区进行电刺激，可导致免疫反应性生长抑素（IRS）分泌率及其在垂体门脉血中的浓度显著增加。相比之下，刺激腹内侧核并未引起垂体门脉免疫反应性生长抑素的任何变化。对视前区进行电刺激可使门脉血流速度也显著增加，但对腹内侧下丘脑进行电刺激则不然。这些发现支持了以下观点，即视前区通过增加生长抑素向大鼠垂体门脉血管的释放，在生长激素分泌调节中发挥抑制作用。
