鞘内化疗。细胞毒性药物的选择。
Intrathecal chemotherapy. Selection of cytostatic agents.
作者信息
Hayakawa T, Yamada R, Kanai N, Kuroda R, Ushio Y, Higashi H, Mogami H
出版信息
Br J Cancer. 1970 Sep;24(3):489-97. doi: 10.1038/bjc.1970.59.
Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of various cytostatic agents. As a result, it may be concluded that Methotrexate and Endoxan and lower dose of mitomycin C are suitable drugs for intrathecal chemotherapy.Based on these findings, clinical cases of malignant brain tumours were treated with intrathecal chemotherapy.Grateful acknowledgement is made to Professor Dennosuke Jinnai for his constant interest and guidance in this investigation.
鞘内给药的细胞抑制剂的选择是本文的主题。研究了多种细胞抑制剂鞘内给药对血脑屏障的毒性副作用（破坏血脑屏障和体重变化）以及对颅内移植吉田腹水肉瘤的细胞抑制作用。结果表明，甲氨蝶呤、环磷酰胺和低剂量丝裂霉素C是适合鞘内化疗的药物。基于这些发现，对恶性脑肿瘤临床病例进行了鞘内化疗。衷心感谢神内哲之助教授在本研究中给予的持续关注和指导。
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