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氧化氘对棕刺毛鼠(Mus platythrix Bennett)垂体促性腺细胞的影响

Effect of deuterium oxide on the pituitary gonadotrophs of the brown spiny mouse. Mus platythrix Bennett.

作者信息

Madhyastha N A, Gopal Dutt N H

出版信息

Endokrinologie. 1979;73(3):273-8.

PMID:499095
Abstract

Adult individuals of M. platythrix were maintained on 30 per cent D2O by volume in drinking water at varying periods of time. Qualitative and quantitative changes in pituitary FSH and LH cells were observed. The former revealed hyperplasia and hypertrophy by 10 days attaining their peak of activity and hyalinization by 20 days. In contrast response in the LH cells was rather slow. They showed a significant increase in number after 30 days and hyalinization by 50 days. FSH cells revealed decline in activity by 50 days whereas LH cells attained their peak numerically by 40 days and underwent no change thereafter. These observations suggest that in the adult male D2O reveals: 1. hyperactive influence on the gonadotrophs, and 2. differential in FSH and LH secreting cells.

摘要

成年的扁鼻猴个体在不同时间段饮用含30%(按体积计)重水的饮用水。观察垂体促卵泡激素(FSH)和促黄体生成素(LH)细胞的定性和定量变化。FSH细胞在10天时出现增生和肥大,达到活性峰值,20天时出现透明变性。相比之下,LH细胞的反应相当缓慢。它们在30天后数量显著增加,50天时出现透明变性。FSH细胞在50天时活性下降,而LH细胞在40天时数量达到峰值,此后没有变化。这些观察结果表明,成年雄性饮用重水后表现出:1. 对促性腺细胞有过度活跃的影响;2. FSH和LH分泌细胞存在差异。

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