关于博来霉素的作用机制。博来霉素导致的DNA链断裂及其在体外与DNA的结合。 - Suppr

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On the mechanism of action of bleomycin. Strand scission of DNA caused by bleomycin and its binding to DNA in vitro.

作者信息

Suzuki H, Nagai K, Akutsu E, Yamaki H, Tanaka N

出版信息

J Antibiot (Tokyo). 1970 Oct;23(10):473-80.

PMID:4991640

Abstract

摘要

相似文献

On the mechanism of action of bleomycin. Strand scission of DNA caused by bleomycin and its binding to DNA in vitro.

J Antibiot (Tokyo). 1970 Oct;23(10):473-80.

Fragmentation of deoxyribonucleic acid by bleomycin.

Mol Pharmacol. 1971 Nov;7(6):645-52.

On the mechanism of action of bleomycin: scission of DNA strands in vitro and in vivo.

J Antibiot (Tokyo). 1969 Sep;22(9):446-8. doi: 10.7164/antibiotics.22.446.

Strand-scission of HeLa cell deoxyribonucleic acid by bleomycin in vitro and in vivo.

Biochem Pharmacol. 1973 Feb 1;22(3):323-33. doi: 10.1016/0006-2952(73)90413-9.

Release of free bases from deoxyribonucleic acid after reaction with bleomycin.

Mol Pharmacol. 1972 Sep;8(5):531-7.

Effect of ethylendiaminetetraacetate on Escherichia coli B ribosomes--binding of phenylalanyl sRNA to 50S particles converted from 70S ribosomes.

Biochem Biophys Res Commun. 1967 Dec 15;29(5):667-73. doi: 10.1016/0006-291x(67)90268-9.

Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of 2-mercaptoethanol.

J Antibiot (Tokyo). 1969 Nov;22(11):569-73. doi: 10.7164/antibiotics.22.569.

Reaction of bleomycin with DNA. Strand scission of DNA in the absence of sulfhydryl or peroxide compounds.

J Antibiot (Tokyo). 1971 Nov;24(11):761-6.

[Ribosomes of Escherichia coli. IV. Study of reversible dissociation of RNA 5S by unfolding of the sub-unit 5OS].

Bull Soc Chim Biol (Paris). 1970 Jul 18;52(6):607-19.

Studies on the succinylation of rat-liver ribosomes.

S Afr J Med Sci. 1968 Apr;33(1):1-8.

引用本文的文献

In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae.

G3 (Bethesda). 2023 Aug 9;13(8). doi: 10.1093/g3journal/jkad049.

Role for DNA double strand end-resection activity of RecBCD in control of aberrant chromosomal replication initiation in Escherichia coli.

Nucleic Acids Res. 2022 Aug 26;50(15):8643-8657. doi: 10.1093/nar/gkac670.

Essential Role for an Isoform of Escherichia coli Translation Initiation Factor IF2 in Repair of Two-Ended DNA Double-Strand Breaks.

J Bacteriol. 2022 Apr 19;204(4):e0057121. doi: 10.1128/jb.00571-21. Epub 2022 Mar 28.

The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence.

J Biol Inorg Chem. 2017 Aug;22(6):881-892. doi: 10.1007/s00775-017-1466-z. Epub 2017 May 16.

The disaccharide moiety of bleomycin facilitates uptake by cancer cells.

J Am Chem Soc. 2014 Oct 1;136(39):13641-56. doi: 10.1021/ja507255g. Epub 2014 Sep 23.

Phleomycin increases transformation efficiency and promotes single integrations in Schizophyllum commune.

Appl Environ Microbiol. 2009 Mar;75(5):1243-7. doi: 10.1128/AEM.02162-08. Epub 2008 Dec 29.

Protective mechanisms against the antitumor agent bleomycin: lessons from Saccharomyces cerevisiae.

Curr Genet. 2003 Jul;43(4):213-24. doi: 10.1007/s00294-003-0396-1. Epub 2003 Apr 16.

Fission yeast Rad26 is a regulatory subunit of the Rad3 checkpoint kinase.

Mol Biol Cell. 2002 Feb;13(2):480-92. doi: 10.1091/mbc.01-03-0104.

Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage.

EMBO J. 1998 Apr 1;17(7):2055-66. doi: 10.1093/emboj/17.7.2055.

Mechanism of action of cinodine, a glycocinnamoylspermidine antibiotic.

Antimicrob Agents Chemother. 1981 Oct;20(4):425-32. doi: 10.1128/AAC.20.4.425.

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On the mechanism of action of bleomycin. Strand scission of DNA caused by bleomycin and its binding to DNA in vitro.

作者信息

Suzuki H, Nagai K, Akutsu E, Yamaki H, Tanaka N

出版信息

J Antibiot (Tokyo). 1970 Oct;23(10):473-80.

PMID:4991640

Abstract

摘要

相似文献

On the mechanism of action of bleomycin. Strand scission of DNA caused by bleomycin and its binding to DNA in vitro.

J Antibiot (Tokyo). 1970 Oct;23(10):473-80.

Fragmentation of deoxyribonucleic acid by bleomycin.

Mol Pharmacol. 1971 Nov;7(6):645-52.

On the mechanism of action of bleomycin: scission of DNA strands in vitro and in vivo.

J Antibiot (Tokyo). 1969 Sep;22(9):446-8. doi: 10.7164/antibiotics.22.446.

Strand-scission of HeLa cell deoxyribonucleic acid by bleomycin in vitro and in vivo.

Biochem Pharmacol. 1973 Feb 1;22(3):323-33. doi: 10.1016/0006-2952(73)90413-9.

Release of free bases from deoxyribonucleic acid after reaction with bleomycin.

Mol Pharmacol. 1972 Sep;8(5):531-7.

Effect of ethylendiaminetetraacetate on Escherichia coli B ribosomes--binding of phenylalanyl sRNA to 50S particles converted from 70S ribosomes.

Biochem Biophys Res Commun. 1967 Dec 15;29(5):667-73. doi: 10.1016/0006-291x(67)90268-9.

Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of 2-mercaptoethanol.

J Antibiot (Tokyo). 1969 Nov;22(11):569-73. doi: 10.7164/antibiotics.22.569.

Reaction of bleomycin with DNA. Strand scission of DNA in the absence of sulfhydryl or peroxide compounds.

J Antibiot (Tokyo). 1971 Nov;24(11):761-6.

[Ribosomes of Escherichia coli. IV. Study of reversible dissociation of RNA 5S by unfolding of the sub-unit 5OS].

Bull Soc Chim Biol (Paris). 1970 Jul 18;52(6):607-19.

Studies on the succinylation of rat-liver ribosomes.

S Afr J Med Sci. 1968 Apr;33(1):1-8.

引用本文的文献

In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae.

G3 (Bethesda). 2023 Aug 9;13(8). doi: 10.1093/g3journal/jkad049.

Role for DNA double strand end-resection activity of RecBCD in control of aberrant chromosomal replication initiation in Escherichia coli.

Nucleic Acids Res. 2022 Aug 26;50(15):8643-8657. doi: 10.1093/nar/gkac670.

Essential Role for an Isoform of Escherichia coli Translation Initiation Factor IF2 in Repair of Two-Ended DNA Double-Strand Breaks.

J Bacteriol. 2022 Apr 19;204(4):e0057121. doi: 10.1128/jb.00571-21. Epub 2022 Mar 28.

The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence.

J Biol Inorg Chem. 2017 Aug;22(6):881-892. doi: 10.1007/s00775-017-1466-z. Epub 2017 May 16.

The disaccharide moiety of bleomycin facilitates uptake by cancer cells.

J Am Chem Soc. 2014 Oct 1;136(39):13641-56. doi: 10.1021/ja507255g. Epub 2014 Sep 23.

Phleomycin increases transformation efficiency and promotes single integrations in Schizophyllum commune.

Appl Environ Microbiol. 2009 Mar;75(5):1243-7. doi: 10.1128/AEM.02162-08. Epub 2008 Dec 29.

Protective mechanisms against the antitumor agent bleomycin: lessons from Saccharomyces cerevisiae.

Curr Genet. 2003 Jul;43(4):213-24. doi: 10.1007/s00294-003-0396-1. Epub 2003 Apr 16.

Fission yeast Rad26 is a regulatory subunit of the Rad3 checkpoint kinase.

Mol Biol Cell. 2002 Feb;13(2):480-92. doi: 10.1091/mbc.01-03-0104.

Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage.

EMBO J. 1998 Apr 1;17(7):2055-66. doi: 10.1093/emboj/17.7.2055.

Mechanism of action of cinodine, a glycocinnamoylspermidine antibiotic.

Antimicrob Agents Chemother. 1981 Oct;20(4):425-32. doi: 10.1128/AAC.20.4.425.