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组胺在疟疾中的作用。

The effects of histamine in malaria.

作者信息

Maegraith B G, Onabanjo A O

出版信息

Br J Pharmacol. 1970 Aug;39(4):755-64. doi: 10.1111/j.1476-5381.1970.tb09902.x.

DOI:10.1111/j.1476-5381.1970.tb09902.x
PMID:4991928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1702718/
Abstract
  1. Extracts of the blood of monkeys (Macaca mulatta) infected with Plasmodium knowlesi contain histamine. A mean total concentration of 0.15 mug/ml was present in the circulating blood.2. No histamine was detected in the blood of healthy monkeys.3. Vasodilatation and increased vascular permeability was observed at the site of injection of the extract into the skin and brain of guinea-pigs.4. Infiltration of the dermal layer by leucocytes was observed after intradermal injection of the histamine extract. A similar response was obtained in the brain.5. The extract of the blood from the infected animal produced hypotension in rabbits when administered intravenously.6. The pathophysiological significance of histamine in malaria is discussed.
摘要

  1. 感染诺氏疟原虫的恒河猴血液提取物中含有组胺。循环血液中的平均总浓度为0.15微克/毫升。

  2. 在健康猴子的血液中未检测到组胺。

  3. 将提取物注射到豚鼠的皮肤和脑部后，观察到注射部位血管扩张和血管通透性增加。

  4. 皮内注射组胺提取物后，观察到白细胞浸润真皮层。在脑部也获得了类似的反应。

  5. 静脉注射感染动物的血液提取物会使兔子出现低血压。

  6. 讨论了组胺在疟疾中的病理生理意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/495223f82f65/brjpharm00562-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/8e9d4545625e/brjpharm00562-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/096c64dba84f/brjpharm00562-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/659c99c55ba9/brjpharm00562-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/495223f82f65/brjpharm00562-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/8e9d4545625e/brjpharm00562-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/096c64dba84f/brjpharm00562-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/659c99c55ba9/brjpharm00562-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faec/1702718/495223f82f65/brjpharm00562-0111-a.jpg

相似文献

1
The effects of histamine in malaria.组胺在疟疾中的作用。
Br J Pharmacol. 1970 Aug;39(4):755-64. doi: 10.1111/j.1476-5381.1970.tb09902.x.
2
Pathological lesions produced in the brain by kllikrein (kininogenase) in Macaca mulatta infected with Plasmodium knowlesi.感染诺氏疟原虫的恒河猴中，激肽释放酶（激肽原酶）在其大脑中产生的病理损伤。
Ann Trop Med Parasitol. 1970 Jun;64(2):237-42. doi: 10.1080/00034983.1970.11686686.
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Inflammatory changes in small blood vessels induced by kallikrein (kininogenase) in the blood of Macaca mulatta infected with Plasmodium knowlesi.感染诺氏疟原虫的恒河猴血液中激肽释放酶（激肽原酶）诱导的小血管炎症变化。
Ann Trop Med Parasitol. 1970 Jun;64(2):227-36. doi: 10.1080/00034983.1970.11686685.
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West Afr J Pharmacol Drug Res. 1974 Jan;1(1):24-31.
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Kallikrein as a pathogenic agent in Plasmodium knowlesi infection in Macaca mulatta.激肽释放酶作为食蟹猴诺氏疟原虫感染中的一种致病因子。
Br J Exp Pathol. 1970 Oct;51(5):523-33.
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The probable pathogenic role of adenosine in malaria.腺苷在疟疾中可能的致病作用。
Br J Exp Pathol. 1970 Dec;51(6):581-6.
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Delayed dermal hypersensitivity in rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi.针对诺氏疟原虫免疫的恒河猴（猕猴）的迟发性皮肤超敏反应。
Z Parasitenkd. 1976 Jul 27;50(1):31-42. doi: 10.1007/BF00389929.
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Int Immunopharmacol. 2003 Nov;3(12):1563-8. doi: 10.1016/S1567-5769(03)00009-2.
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Production and antagonism of cutaneous vascular permeability in the guinea pig in response to histamine, leukotrienes and A23187.豚鼠皮肤血管通透性对组胺、白三烯和A23187的产生及拮抗作用
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Effects of vasodilators on filtration coefficient and distal arterial pressure in muscle.血管扩张剂对肌肉滤过系数和远端动脉压的影响。
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2
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本文引用的文献

1
The pharmacological estimation of adenosine and histamine in blood.血液中腺苷和组胺的药理学评估。
J Physiol. 1935 Aug 22;85(1):1-14. doi: 10.1113/jphysiol.1935.sp003298.
2
The vasodilator action of histamine and of some other substances.组胺及其他一些物质的血管舒张作用。
J Physiol. 1918 Jul 10;52(2-3):110-65. doi: 10.1113/jphysiol.1918.sp001825.
3
Further observations on the action of beta-iminazolylethylamine.关于β-咪唑基乙胺作用的进一步观察
Cardiovasc J Afr. 2012 Mar;23(2):98-102. doi: 10.5830/CVJA-2011-059.
J Physiol. 1911 Oct 20;43(2):182-95. doi: 10.1113/jphysiol.1911.sp001464.
4
The physiological action of beta-iminazolylethylamine.β-咪唑基乙胺的生理作用。
J Physiol. 1910 Dec 31;41(5):318-44. doi: 10.1113/jphysiol.1910.sp001406.
5
The physiological approach to the problems of malaria.疟疾问题的生理学研究方法。
Br Med Bull. 1951;8(1):28-32. doi: 10.1093/oxfordjournals.bmb.a074050.
6
Relationship of induced histidine decarboxylase activity and histamine synthesis to shock from stress and from endotoxin.诱导型组氨酸脱羧酶活性及组胺合成与应激性休克和内毒素性休克的关系。
Am J Physiol. 1960 Jun;198:1187-92. doi: 10.1152/ajplegacy.1960.198.6.1187.
7
THE CIRCULATION IN MALARIA. II. PORTAL ANGIOGRAPHY IN MONKEYS (MACACA MULATTA) INFECTED WITH PLASMODIUM KNOWLESI AND IN SHOCK FOLLOWING MANIPULATION OF THE GUT.疟疾中的循环。二。感染诺氏疟原虫的恒河猴（猕猴）的门静脉血管造影及肠道操作后的休克
Ann Trop Med Parasitol. 1964 Dec;58:502-10.
8
Pharmacologically active peptides in the blood and urine of animals infected with Babesia rodhaini and other pathogenic organisms.感染罗氏巴贝斯虫和其他致病生物的动物血液及尿液中的药理活性肽。
Br J Pharmacol Chemother. 1960 Mar;15(1):152-9. doi: 10.1111/j.1476-5381.1960.tb01224.x.
9
Mechanism of histamine release in endotoxin shock.内毒素休克中组胺释放的机制。
Am J Physiol. 1961 May;200:987-9. doi: 10.1152/ajplegacy.1961.200.5.987.
10
The involvement of histamine in malaria.组胺在疟疾中的作用。
Br J Pharmacol. 1969 Oct;37(2):535P-536P.