Markiewicz W, Peled B, Alroy G, Pollack S, Brook G, Rapoport J, Kerner H
Eur J Cardiol. 1979 Oct;10(4):247-57.
59 patients with suspected infective endocarditis on a natural valve were studied by M-Mode echocardiography to determine the specificity of the ultrasonic technique in detecting valvular vegetations. All echocardiograms were read independently by two observers who were unaware of the final diagnosis. Among 40 patients who later proved not to have infective endocarditis, two (5%) were diagnosed by echocardiography as having either possible or probably vegetation by at least one observer. Both patients with a false positive diagnosis of vegetation had pre-existing valvular pathology, the presence of which greatly complicated the interpretation of the echocardiogram. Inter-observer disagreement occurred in 5 of the 59 studies (8.5%). The results of this study suggest that caution should be exerted in the echocardiographic diagnosis of vegetation in patients with pre-existing valvular pathology.
对59例疑似天然瓣膜感染性心内膜炎的患者进行了M型超声心动图检查，以确定超声技术检测瓣膜赘生物的特异性。所有超声心动图均由两名不知最终诊断结果的观察者独立解读。在后来证实没有感染性心内膜炎的40例患者中，至少有一名观察者通过超声心动图诊断出两名（5%）可能或很可能有赘生物。两名赘生物诊断为假阳性的患者均有既往瓣膜病变，其存在极大地复杂化了超声心动图的解读。59项研究中有5项（8.5%）存在观察者间分歧。本研究结果提示，对于有既往瓣膜病变的患者，在超声心动图诊断赘生物时应谨慎。
