Chevillard C, Duchene N, Pasquier R, Alexandre J M
Eur J Pharmacol. 1979 Sep 15;58(2):203-6. doi: 10.1016/0014-2999(79)90013-x.
Experiments were performed in urethane-anaesthetized rabbits using ventriculo-cisternol perfusion. Central infusion of angiotensin II (50 ng/kg/min) induced a rise in blood pressure which was accompanied by an increase in the noradrenaline concentration of the cerebrospinal fluid. Both effects were highly correlated. Conversely, an i.v. infusion of noradrenaline (5 micrograms/kg/min) which caused a similar increase in arterial pressure did not affect the cerebrospinal fluid catecholamine levels. These results suggest that peripheral cardiovascular effects of centrally administered angiotensin II are related to the activation of noradrenaline structures in the brain.
在使用脑室-脑池灌注的氨基甲酸乙酯麻醉兔身上进行了实验。向中枢输注血管紧张素II（50纳克/千克/分钟）可导致血压升高，同时脑脊液中去甲肾上腺素浓度增加。这两种效应高度相关。相反，静脉输注去甲肾上腺素（5微克/千克/分钟）虽然导致动脉压有类似升高，但并未影响脑脊液中儿茶酚胺水平。这些结果表明，中枢给予血管紧张素II的外周心血管效应与脑中去甲肾上腺素结构的激活有关。
