Zhukova N A, Maksimenko A A
Farmakol Toksikol. 1979 Nov-Dec;42(6):647-50.
Single intraperitoneal administration of dextran sulfate to noninbred mice at a dose of 60 mg/kg 3--24 and 48 hours prior to irradiation in lethal and sublethal doses exerts no radioprotective action. Administration of the drug 24 hours before irradiation increases the intensity of postradiation leukopenia. During irradiation of the animals in a dose of 650 rad dextran sulfate accelerates the recovery of hemopoiesis. With the dose of irradiation being increased up to 750 rad, the drug produces no effect on this parameter.
在非近交系小鼠中，于致死剂量和亚致死剂量照射前3至24小时及48小时，以60毫克/千克的剂量腹腔内单次注射硫酸葡聚糖，未产生辐射防护作用。在照射前24小时给药会增加辐射后白细胞减少的强度。当以650拉德的剂量照射动物时，硫酸葡聚糖可加速造血功能的恢复。当照射剂量增加至750拉德时，该药物对这一参数无影响。
