[制剂对大鼠甲状腺素抑制代偿性甲状腺肥大能力的影响]
[Effect of preparations on the capacity of thyroxine to suppress compensatory thyroid hypertrophy in rats].
作者信息
Bershteĭn L M
出版信息
Farmakol Toksikol. 1979 Nov-Dec;42(6):651-4.
PMID:499475
Abstract
It has been shown in compensatory hypertrophy of the thyroid gland of male rats weighing 180--240 g that of 18 compounds tested five drugs (cyclic AMP, theophylline, phenformin, tryptophan and disulfiram) reduce an inhibitory effect of thyroxin and are likely to raise the threshold of homeostatic inhibition in the hypothalamohypophyseal and thyroid system.
摘要
在体重为180 - 240克的雄性大鼠甲状腺代偿性肥大实验中发现，在所测试的18种化合物中，有5种药物（环磷酸腺苷、茶碱、苯乙双胍、色氨酸和双硫仑）可降低甲状腺素的抑制作用，并可能提高下丘脑 - 垂体和甲状腺系统稳态抑制的阈值。
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